{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:28:43Z","timestamp":1789673323965,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:00:00Z","timestamp":1701475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01754"],"award-info":[{"award-number":["PI17\/01754"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal iron supplementation improves children's health and cognitive performance, but few studies explore behavioural development. This study assessed the effects of adjusting prenatal iron supplementation to maternal iron stores during early pregnancy on children's behavioural problems. Randomized controlled trial conducted in Tarragona (Spain) involving 230 nonanaemic pregnant women and their children after a 4\u2010year follow\u2010up. Based on haemoglobin (Hb) levels before gestational week (GW) 12, women receive different iron doses: those with Hb\u2009=\u2009110\u2013130\u2009g\/L were randomized to receive 80 or 40\u2009mg\/day and those with Hb\u2009&gt;\u2009130\u2009g\/L were randomized to receive 20 or 40\u2009mg\/day. Maternal iron stores at GW12 were classified using serum ferritin (SF) as low (SF\u2009&lt;\u200915\u2009\u00b5g\/L), normal (SF\u2009=\u200915\u201365\u2009\u00b5g\/L), and normal\u2010high (SF\u2009&gt;\u200965\u2009\u00b5g\/L). Children's behaviour was assessed by parents using the Child Behaviour Checklist for ages 1.5\u20135 years and the Behaviour Rating Inventory of Executive Function\u2010Preschool Version, and by teachers using the Teacher's Report Form for ages 1.5\u20135 years. Multivariable regression models were performed. Taking 80\u2009mg\/day of iron improved child behaviour when women had low iron stores but worsened it when mothers had normal\u2013high iron stores, except for depressive and attention\/hyperactivity problems. Taking 20\u2009mg\/day of iron improved behaviour only in those children whose mothers had SF\u2009&gt;\u200965\u2009\u00b5g\/L in early pregnancy. Additionally, executive functioning improved at high doses of prenatal iron when maternal baseline SF\u2009&lt;\u200915\u2009\u00b5g\/L. Adjusting prenatal iron supplementation to both maternal baseline Hb levels and iron stores reduces behavioural problems in 4\u2010year\u2010old children.<\/jats:p>","DOI":"10.1111\/mcn.13595","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T19:26:41Z","timestamp":1701545201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prenatal iron supplementation adjusted to maternal iron stores reduces behavioural problems in 4\u2010year\u2010old children"],"prefix":"10.1111","volume":"20","author":[{"given":"Luc\u00eda","family":"Iglesias\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Nutrition and Mental Health (NUTRISAM) Research Group Universitat Rovira I Virgili Reus Spain"},{"name":"Institut d'Investigaci\u00f3 Sanitaria Pere Virgili (IISPV) Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Canals","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Nutrition and Mental Health (NUTRISAM) Research Group Universitat Rovira I Virgili Reus Spain"},{"name":"Department of Psychology, Research Centre for Behavioral Assessment (CRAMC), Faculty of Education Sciences and Psychology Universitat Rovira I Virgili  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Hern\u00e1ndez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Nutrition and Mental Health (NUTRISAM) Research Group Universitat Rovira I Virgili Reus Spain"},{"name":"Department of Psychology, Research Centre for Behavioral Assessment (CRAMC), Faculty of Education Sciences and Psychology Universitat Rovira I Virgili  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Voltas","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Nutrition and Mental Health (NUTRISAM) Research Group Universitat Rovira I Virgili Reus Spain"},{"name":"Department of Psychology, Research Centre for Behavioral Assessment (CRAMC), Faculty of Education Sciences and Psychology Universitat Rovira I Virgili  Tarragona Spain"},{"name":"Department of Psychology, Faculty of Education Sciences and Psychology, Serra H\u00fanter Fellow Universitat Rovira I Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-0975","authenticated-orcid":false,"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Nutrition and Mental Health (NUTRISAM) Research Group Universitat Rovira I Virgili Reus Spain"},{"name":"Institut d'Investigaci\u00f3 Sanitaria Pere Virgili (IISPV) Reus Spain"},{"name":"Collaborative Research Group on Lifestyles, Nutrition, and Smoking (CENIT), Tarragona\u2010Reus Research Support Unit IDIAP Jordi Gol Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,2]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Achenbach T. 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