{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:53:33Z","timestamp":1792706013586,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory diseases in childhood. Among\u00a01243 formula\u2010fed children from the EDEN mother\u2013child cohort, IF characteristics concerning long\u2010chain polyunsaturated fatty acids (LCPUFAs) enrichment, prebiotic\/probiotic enrichment, and hydrolysis of proteins were identified from the ingredients list. Eczema, wheezing, food allergy, asthma, and allergic rhinitis up to age 8 years were prospectively collected and summarized into four allergic and respiratory multimorbidity clusters. Associations between 4\u2010month IF characteristics and risk of allergy or respiratory diseases were tested using logistic regressions adjusted on main confounders. The consumption of LCPUFA\u2010enriched formula was not linked to allergic and respiratory multimorbidity clusters, but to a lower risk of any allergy, eczema, and wheezing. Probiotic\u2010enriched formula consumption was associated with a lower risk of belonging to the \u2018Allergy without asthma\u2019 cluster (odds ratio [OR]\u00a0[95% confidence interval,\u00a0CI]\u2009=\u20090.63 [0.40\u20130.99]), and consumption of a formula enriched in <jats:italic>Bifidobacterium lactis<\/jats:italic> was associated with a lower risk of any allergy (OR\u00a0[95% CI]\u2009=\u20090.59 [0.41\u20130.85]). Partially hydrolysed formula (pHF) consumption was associated with a higher risk of belonging to the \u2018Allergy without asthma\u2019 cluster (OR\u00a0[95%\u00a0CI]\u2009=\u20092.73 [1.65\u20134.51]). This study confirms the positive association between pHF\u00a0consumption and the risk of allergy found in previous observational studies and suggests that consumption of LCPUFA\u2010enriched or probiotic\u2010enriched formula was associated with a lower risk of allergy.<\/jats:p>","DOI":"10.1111\/mcn.13673","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:10:16Z","timestamp":1716556216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother\u2013child cohort"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-3582","authenticated-orcid":false,"given":"Moufidath","family":"Adjibade","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille","family":"Vigneron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-8071","authenticated-orcid":false,"given":"Rosalie","family":"Delvert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Univ. Paris\u2010Sud, Inserm, \u00c9quipe d'\u00c9pid\u00e9miologie respiratoire int\u00e9grative, CESP Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-0626","authenticated-orcid":false,"given":"Karine","family":"Adel\u2010Patient","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, CEA, INRAE, DMTS Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-9864","authenticated-orcid":false,"given":"Amandine","family":"Divaret\u2010Chauveau","sequence":"additional","affiliation":[{"name":"UR 3450, Laboratoire DevAH, Universit\u00e9 de Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Unit\u00e9 d'allergologie p\u00e9diatrique, H\u00f4pital d'Enfants, CHRU de Nancy Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Annesi\u2010Maesano","sequence":"additional","affiliation":[{"name":"Desbrest Institute of Epidemiology and Public Health (IDESP), Montpellier University and INSERM Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-1629","authenticated-orcid":false,"given":"Barbara","family":"Heude","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-4390","authenticated-orcid":false,"given":"Marie\u2010Aline","family":"Charles","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris France"},{"name":"Unit\u00e9 mixte Inserm\u2010Ined\u2010EFS Elfe, INED Aubervilliers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-8842","authenticated-orcid":false,"given":"Blandine","family":"de Lauzon\u2010Guillain","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15137"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxac013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14568"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"21","article-title":"The use of sample weights in hot deck imputation","volume":"25","author":"Andridge R. 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