{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:37:43Z","timestamp":1793327863782,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optimal maternal nutrition, including adequate intake and status of essential micronutrients, is important for the health of women and developing infants. Currently, the World Health Organization (WHO) <jats:italic>Antenatal care recommendations for a positive pregnancy experience<\/jats:italic> recommend daily iron and folic acid (IFA) supplementation as the standard of care. The use of multiple micronutrient supplements (MMS) is recommended in the context of rigorous research as more evidence was needed regarding the impact of switching from IFA supplements to MMS, including evaluation of critical clinical maternal and perinatal outcomes, acceptability, feasibility, sustainability, equity and cost\u2010effectiveness. WHO convened a technical consultation of key stakeholders to discuss research priorities with the objective of providing guidance and clarity to donors, implementers and researchers about this recommendation. The overarching principles of the research agenda include the use of clinical indicators and impact measures that are applicable across studies and settings and the inclusion of outcomes that are important to women. Future studies should consider using standardized protocols based on current best practices to measure critical outcomes such as gestational age (GA) and birthweight (BW) in studies. As GA and BW are influenced by multiple factors, more research is needed to understand the biological impact pathways, and how initiation and considerations for timing of MMS influence these outcomes. A set of core clinical indicators was agreed upon during the technical consultation. For implementation research, the Evidence\u2010to\u2010Decision framework was used as a resource for discussing components of implementation research. The implementation research questions, key indicators and performance measures will depend on country\u2010specific context and bottlenecks that require further research and improved solutions to enable the successful implementation of iron\u2010containing supplements.<\/jats:p>","DOI":"10.1111\/mcn.13722","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T10:42:28Z","timestamp":1727865748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of multiple micronutrient supplementation integrated into routine antenatal care: A discussion of research priorities"],"prefix":"10.1111","volume":"21","author":[{"given":"Tabassum","family":"Firoz","sequence":"first","affiliation":[{"name":"Yale New Haven Health New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahnavi","family":"Daru","sequence":"additional","affiliation":[{"name":"Wolfson Institute for Population Health Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Busch\u2010Hallen","sequence":"additional","affiliation":[{"name":"Global Technical Services Nutrition International Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"Tun\u00e7alp","sequence":"additional","affiliation":[{"name":"Department of Sexual and Reproductive Health and Research including UNDP\/UNFPA\/UNICEF\/WHO\/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP) World Health Organization (WHO) Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Safety World Health Organization (WHO) Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.091546"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.207225"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00354-9"},{"key":"e_1_2_11_5_1","unstructured":"deOnis M. Cheikh Ismail L. Chumlea C. Onyango A. Bhutta Z. Luna M. S. &Knight H.(2012).INTERGROWTH\u201021st: International fetal and newborn growth standards for the 21st century: Anthropometry handbook.https:\/\/media.tghn.org\/articles\/Anthropometry_Handbook_April_2012.pdf"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogn.2019.09.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.06.005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14756"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980022001008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.13509"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14539"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522003889"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002220"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00207-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-023-01653-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-023-01653-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12478"},{"key":"e_1_2_11_19_1","unstructured":"National Library of Medicine (U.S.). (2024).Multiple micronutrient supplementation for maternal anemia prevention in Tanzania (MMS\u2010MAP). Identifier NCT06079918.https:\/\/clinicaltrials.gov\/study\/NCT06079918"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2022-011170"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15894"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13448"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxz046"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj8016"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00367-9"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2020-003375"},{"key":"e_1_2_11_27_1","volume-title":"Multiple micronutrient supplementation during pregnancy (MMSDP): Efficacy trials","author":"UNICEF, UNU, WHO Study Team","year":"2002"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2019-001683"},{"key":"e_1_2_11_29_1","volume-title":"Composition of a multi\u2010micronutrient supplement to be used in pilot programmes among pregnant women in developing countries: Report of a United Nations Children's Fund (\u200eUNICEF)\u200e","author":"World Health Organization, United Nations University, & United Nations Children's Fund (\u200eUNICEF)","year":"1999"},{"key":"e_1_2_11_30_1","unstructured":"World Health Organization. (2016a).International statistical classification of diseases and related health problems 10th revision.https:\/\/icd.who.int\/browse10\/2019\/en"},{"key":"e_1_2_11_31_1","unstructured":"World Health Organization. (2016b).WHO recommendations on antenatal care for a positive pregnancy experience: Web annexes.https:\/\/iris.who.int\/bitstream\/handle\/10665\/250796\/9789241549912-webannexes-eng.pdf"},{"key":"e_1_2_11_32_1","unstructured":"World Health Organization. (2016c).WHO recommendations on antenatal care for a positive pregnancy experience.http:\/\/www.who.int\/publications\/i\/item\/9789241549912"},{"key":"e_1_2_11_33_1","unstructured":"World Health Organization. (2020).WHO antenatal care recommendations for a positive pregnancy experience: Nutritional interventions update: Multiple micronutrient supplements during pregnancy.https:\/\/www.who.int\/publications\/i\/item\/9789240007789"}],"container-title":["Maternal &amp; Child Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.13722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T09:56:40Z","timestamp":1734429400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mcn.13722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/mcn.13722"],"URL":"https:\/\/doi.org\/10.1111\/mcn.13722","archive":["Portico"],"relation":{},"ISSN":["1740-8695","1740-8709"],"issn-type":[{"value":"1740-8695","type":"print"},{"value":"1740-8709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]},"assertion":[{"value":"2024-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13722"}}