{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:12:45Z","timestamp":1784218365171,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The relationship between the famine and metabolic syndrome has been reported, but there is a lack of more detailed changes in metabolic profiles. It is unclear how famine affects body composition. This study included 21,142 participants from the China National Health Survey. The body mass index (BMI), fat mass index (FMI), and fat\u2010free mass index (FFMI) were calculated. Systolic blood pressure (SBP), diastolic blood pressure (DBP), blood lipids, and fasting blood glucose (FBG) were measured. Multivariate adjusted linear regression models were used to assess the association between famine and outcome. Our results shown that fetal\u2010exposed group had higher BMI and FMI (<jats:italic>\u03b2<\/jats:italic>\u2009&gt;\u20090). Childhood\u2010exposed group showed an average decrease of 0.08 standard deviation (SD) in FFMI, and adolescence\u2010exposed group had lower BMI and FFMI than non\u2010exposed group. SBP were 0.38 SD higher in fetal\u2010exposed group, 0.58 SD higher in childhood\u2010exposed group and 0.85 SD higher in adolescence\u2010exposed group than non\u2010exposed group. Famine\u2010exposed groups had higher total cholesterol (TC), low density lipoprotein\u2010cholesterol (LDL\u2010C), and FBG levels (<jats:italic>\u03b2<\/jats:italic>\u2009&gt;\u20090). For females with famine exposure, they had a higher BMI, FMI, LDL\u2010C, TG, and TC than males. Overall, early famine exposure is associated with increased blood pressure, LDL\u2010C, TC, and FBG. Muscle mass loss in adulthood associated with childhood and adolescence famine exposure. Famine\u2010exposed females appear to have higher levels of body fat and blood lipids.<\/jats:p>","DOI":"10.1111\/mcn.13777","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T11:33:54Z","timestamp":1734435234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood"],"prefix":"10.1111","volume":"21","author":[{"given":"Shuaihua","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanze","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daowei","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology, Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Complex, Severe, and Rare Diseases, Biomedical Engineering Facility of National Infrastructures for Translational Medicine Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science &amp; 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