{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:44:10Z","timestamp":1793335450911,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp;amp; Child Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Maternal anaemia is a significant global health issue that adversely affects both maternal and foetal outcomes, particularly, intrauterine growth restriction (IUGR). This systematic review and meta\u2010analysis aimed to consolidate existing evidence on the impact of maternal anaemia on the risk of IUGR. We conducted a comprehensive search across PubMed, Embase, Cochrane and Web of Science until 28 February 2024. Eligible studies included observational designs that reported maternal anaemia and its association with IUGR or small for gestational age (SGA) outcomes. The pooled odds ratios (ORs) were calculated using a random\u2010effects model and heterogeneity was assessed with the\n                    <jats:italic>I<\/jats:italic>\n                    \u00b2 statistic. The R software (version 4.3) was used for statistical analyses. A total of 38 studies involving 3,871,849 anaemic and 27,978,450 non\u2010anaemic pregnant women were included. The pooled analysis demonstrated that anaemia in pregnancy is associated with a significantly increased risk of IUGR (OR\u2009=\u20091.30, 95% CI: 1.05\u20131.62,\n                    <jats:italic>I<\/jats:italic>\n                    \u00b2\u2009=\u200997%). Subgroup analyses by anaemia severity showed non\u2010significant associations for mild (OR\u2009=\u20090.84, 95% CI: 0.58\u20131.23) and moderate anaemia (OR\u2009=\u20090.98, 95% CI: 0.48\u20131.98), while severe anaemia indicated a higher, though non\u2010significant, risk of IUGR (OR\u2009=\u20091.42, 95% CI: 0.69\u20132.93). Maternal anaemia is associated with a heightened risk of IUGR, highlighting the critical need for effective management and early intervention strategies within prenatal care settings. Future research should focus on elucidating the effects of different severities of anaemia on birth outcomes, including IUGR and long\u2010term effects later in life.\n                  <\/jats:p>","DOI":"10.1111\/mcn.13787","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:49:36Z","timestamp":1744768176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Rajeev","family":"Jayalakshmi","sequence":"first","affiliation":[{"name":"Department of Public Health and Community Medicine Central University of Kerala Tejaswini Hills, Periye Kasaragod Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Gaidhane","sequence":"additional","affiliation":[{"name":"One Health Centre, Datta Meghe Institute of Higher Education, Jawaharlal Nehru Medical College Wardha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhas","family":"Ballal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry School of Sciences JAIN (Deemed to be University) Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Allied Healthcare and Sciences Vivekananda Global University Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahakshit","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Medicine National Institute of Medical Sciences NIMS University Rajasthan Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Chandigarh Pharmacy College, Chandigarh Group of Colleges\u2010Jhanjeri Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ravi Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Raghu Engineering College Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh","family":"Rustagi","sequence":"additional","affiliation":[{"name":"School of Applied and Life Sciences Uttaranchal University Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalaqua Nazli","family":"Khatib","sequence":"additional","affiliation":[{"name":"Division of Evidence Synthesis Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education Wardha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Graphic Era (Deemed to be University) Dehradun India"},{"name":"Department of Allied Sciences Graphic Era Hill University Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed\u2010to\u2010be University) Pune Maharashtra India"},{"name":"Department of Medicine Korea Universtiy  Seoul South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-4702","authenticated-orcid":false,"given":"Sorabh","family":"Lakhanpal","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Lovely Professional University Phagwara India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-2188","authenticated-orcid":false,"given":"Hashem Abu","family":"Serhan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Bushi","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital Saveetha University Chennai India"},{"name":"Evidence for Policy and Learning, Global Center for Evidence Synthesis Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Shabil","sequence":"additional","affiliation":[{"name":"University Center for Research and Development Chandigarh University Mohali Punjab India"},{"name":"Medical Laboratories Techniques Department AL\u2010Mustaqbal University Hillah Babil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2010.01220.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.12.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02382-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191711043"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000215"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7613868"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.928855"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40748-016-0041-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2021.02.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081805"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001835"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-022-01884-w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.06.023"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0464-3"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2023.102593"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00160-6"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2020.108"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.384"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00275.2009"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.623200"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2014.987113"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"7","article-title":"Maternal Anemia With Pregnancy and Its Adverse Effects","volume":"31","author":"Helmy M. E.","year":"2018","journal-title":"Menoufia Medical Journal"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.07.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-065587"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16676"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10006-1133"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2020.3593"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-022-03450-1"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01498-0"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002976"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.05.032"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.562"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020271"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.26719\/2004.10.6.801"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870533"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9101460"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122729"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249365"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4341-9"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2013.869501"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2019.12.007"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17983"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy278"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05817-7"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105155"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50234-w"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-024-04820-1"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13702"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhip.2020.100021"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.107896"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.15.3.125"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12839"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1670795"},{"issue":"3","key":"e_1_2_11_56_1","first-page":"319","article-title":"Hyperinsulinemic Hypoglycemia in Growth Restricted Convalescent Preterm Neonates: Clinical Characteristics and Impediments to Early Diagnosis","volume":"35","author":"Rodrigues M.","year":"2022","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0440-4"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02756-2"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.08.053"},{"issue":"1","key":"e_1_2_11_60_1","first-page":"60","article-title":"How to Perform Meta\u2010Analysis in R: A Simple Yet Comprehensive Guide","volume":"1","author":"Shamim M. A.","year":"2023","journal-title":"The Evidence"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S40070"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000126575.34482.fb"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.47046"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610310001620224"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003557"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1846280"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00084-5"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-021-00411-6"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04152-2"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249978"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.703723"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-63"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040836"},{"issue":"2","key":"e_1_2_11_74_1","article-title":"Perinatal Complications and Long\u2010Term Neurodevelopmental Outcome of Infants With Intrauterine Growth Restriction","volume":"208","author":"Beckerath A.\u2010K.","year":"2013","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.8020"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0625"},{"key":"e_1_2_11_77_1","volume-title":"WHO Global Anaemia Estimates","author":"World Health Organization","year":"2021"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-04636-9"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.947118"}],"container-title":["Maternal &amp; Child Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.13787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T05:04:54Z","timestamp":1756530294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mcn.13787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/mcn.13787"],"URL":"https:\/\/doi.org\/10.1111\/mcn.13787","archive":["Portico"],"relation":{},"ISSN":["1740-8695","1740-8709"],"issn-type":[{"value":"1740-8695","type":"print"},{"value":"1740-8709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"2024-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13787"}}