{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:33Z","timestamp":1753879173431,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vitamin A deficiency remains a major public health problem worldwide, particularly among young children. Capillary blood has the potential for application in vitamin A assessment. The aim of this study is to validate the accuracy of capillary blood for assessing vitamin A nutritional status among young children. Venous and capillary blood samples were simultaneously collected from 1366 healthy children under 7 years of age across 12 regions in China. Retinol was measured using high\u2010performance liquid chromatography\u2010mass spectrometry (HPLC\u2010MS\/MS). The agreement was assessed with Bland\u2013Altman plot, Kappa, and prevalence\u2010adjusted and bias\u2010adjusted kappa (PABAK) values. The sensitivity and specificity were evaluated using the ROC curve method. Venous and capillary retinol levels showed significant differences but were highly correlated with <jats:italic>r<\/jats:italic> of 0.93. Ordinary least squares regression was used to characterize (\u03b2\u2009=\u20090.913) and correct the systematic bias in capillary data (compared to paired venous). Thereafter, Bland\u2010Altman analysis demonstrated that the mean bias of corrected capillary retinol compared to venous retinol was 0.01 (95%CI: \u22120.24, 0.25) \u03bcmol\/L with no significant difference (<jats:italic>p<\/jats:italic>\u2009\uff1e\u20090.05). Corrected capillary retinol showed excellent performance for estimating vitamin A status when compared to venous retinol, with Kappa of 0.77\u20130.83, PABAK of 0.80\u20130.96, sensitivity of 0.86\u20130.91 and specificity of 0.87\u20130.98. Capillary HPLC\u2010MS\/MS method is therefore adequate for assessing vitamin A status of young children after correction for systematic bias.<\/jats:p>","DOI":"10.1111\/mcn.13796","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T11:54:17Z","timestamp":1735905257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of Capillary Blood for Assessing Vitamin A Nutritional Status Among Children Under 7 Years of Age: A Multicenter Study"],"prefix":"10.1111","volume":"21","author":[{"given":"Luanluan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Developmental and Behavioral Pediatrics Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouxun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Developmental and Behavioral Pediatrics Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Child Health Care Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyong","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Developmental and Behavioral Pediatrics The First Hospital of Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meizhu","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Child Health Care The First Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The People's Hospital of Guangxi Zhuang Autonomous Region Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sufei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Child Health Care West China Second University Hospital, Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Hospital of Lanzhou University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Child Health Care Yinchuan Maternity and Child Health Care Hospital Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Child Health Care and Neurological Rehabilitation Sports Center Branch of Dalian Municipal Women 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