{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:50:40Z","timestamp":1758639040890,"version":"3.44.0"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Maternal &amp; Child Nutrition"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cardiometabolic disturbances in pregnancy appear to be associated with inappropriate fetal growth, but evidence from uncomplicated pregnancies is still scarce and, due to varied findings, inconclusive. Moreover, most studies focus on specific markers, often measured at a single gestational time\u2010point. We aimed to assess the associations between maternal cardiometabolic markers, measured in early and late pregnancy, and neonatal size in a Mediterranean cohort of healthy women. Longitudinally, we analyzed 264 mother\u2010neonate pairs. Maternal metabolic markers (glucose, insulin resistance, triglycerides, total cholesterol, HDL\u2010c, LDL\u2010c, and blood pressure (BP)) were assessed in the first (T1) and third (T3) trimesters. Birthweight (g) and head circumference (HC, cm) were assessed in the newborns. Small (SGA, &lt;\u200910th percentile) and large (LGA, &gt;\u200990th percentile) for\u2010gestational\u2010age were the primary outcomes. Multivariable\u2010adjusted linear and logistic regressions were performed. Overall, based on weight and HC at birth, there were 10.5% and 6.4% SGA infants, while 8.1% and 16.7% were LGA, respectively. After adjustments for confounders, maternal T1 triglycerides were positively associated with birthweight (\u03b2:74.81\u2009g per 1\u2010SD increment, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), and higher T1 LDL\u2010c levels increased the risk of LGA newborns (OR:1.64\u2009g per 1\u2010SD increment, <jats:italic>p<\/jats:italic>\u2009=\u20090.046). T3 diastolic\u2010BP was inversely associated with birthweight (\u03b2:\u201086.19\u2009g per 1\u2010SD increment; <jats:italic>p<\/jats:italic>\u2009=\u20090.010) and HC (\u03b2:\u20100.30\u2009g per 1\u2010SD increment; <jats:italic>p<\/jats:italic>\u2009=\u20090.008). High diastolic\u2010BP (\u2265\u200975th percentile, 77\u2009mmHg) was also linked to a higher risk of SGA newborns for both weight (OR:3.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.022) and HC (OR:2.56\u2009g per 1\u2010SD increment, <jats:italic>p<\/jats:italic>\u2009=\u20090.025). In conclusions, elevated maternal lipids in early pregnancy and diastolic BP in late pregnancy adversely impact offspring birth size, highlighting the importance of incorporating metabolic monitoring into routine prenatal care.<\/jats:p>","DOI":"10.1111\/mcn.70086","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T10:37:22Z","timestamp":1754476642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic Markers Associated With Altered Fetal Growth in Mediterranean Cohort"],"prefix":"10.1111","volume":"21","author":[{"given":"Ehsan","family":"Motevalizadeh","sequence":"first","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM) Universitat Rovira i Virgili Reus Spain"},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"D\u00edaz\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM) Universitat Rovira i Virgili Reus Spain"},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Jard\u00ed","sequence":"additional","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM) Universitat Rovira i Virgili Reus Spain"},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) Tarragona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rey\u2010Re\u00f1ones","sequence":"additional","affiliation":[{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) Tarragona Spain"},{"name":"Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Tarragona\u2010Reus Research Support Unit Jordi Gol Primary Care Research Institute Reus Spain"},{"name":"Institut d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol Institut Catal\u00e0 de la Salut (ICS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mart\u00edn\u2010Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) Tarragona Spain"},{"name":"Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Tarragona\u2010Reus Research Support Unit Jordi Gol Primary Care Research Institute Reus Spain"},{"name":"Institut d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol Institut Catal\u00e0 de la Salut (ICS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-0975","authenticated-orcid":false,"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Research Group in Nutrition and Mental Health (NUTRISAM) Universitat Rovira i Virgili Reus Spain"},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) Tarragona Spain"},{"name":"Institut d'Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol Institut Catal\u00e0 de la Salut (ICS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0B013E3181C2BDE8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41372-024-01886-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12916-020-01730-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.6065\/APEM.2346136.068"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-33"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1309383"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/AJE\/KWR151"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/TOG.12887"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12916-016-0692-5\/TABLES\/2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57373-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/JP.2017.22"},{"issue":"6","key":"e_1_2_11_13_1","first-page":"729","article-title":"Maternal Plasma Cytokines Concentrations and Insulin Resistance in First Trimester in Relation to Fetal Growth","volume":"30","author":"Bomba\u2010Opon D. A.","year":"2009","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-10-0088"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)06297-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1464-5491.2004.01336.X"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE.1.02034"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.1979.237.3.E214"},{"volume-title":"Protocol d'activitats Preventives i de Promoci\u00f3 de la salut a l'edat Pedi\u00e0trica: Inf\u00e0ncia amb Salut [Internet]","year":"2008","author":"Direcci\u00f3 General de Salut P\u00fablica de Catalunya","key":"e_1_2_11_20_1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2021.787848\/BIBTEX"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00404-013-2750-Y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NUMECD.2021.04.019"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329-9525.1000127"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00125-019-4957-3"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12884-022-04647-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.666194"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1360-0443.1991.TB01879.X"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-25057-7_5"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/HR.2015.108"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACL.2015.09.002"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/NU11102447"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12884-016-0852-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/IJPO.230"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/JPC.13593"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-024-52154-9"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00423-1"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01328-X"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.293.15.1891"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07838"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12944-018-0936-9"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000368"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02766\/-\/DC1"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.12688\/F1000RESEARCH.26072.2"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/OBY.2011.43"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816181"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000927"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/ER.2005-0011"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMUPD\/DMP050"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174420000586"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12884-020-2834-1"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59940-5"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2020.611929"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12944-022-01664-4\/TABLES\/5"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/IJE\/DYQ267"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/10068.5081"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13474"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903121472"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2012-1295"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12944-020-01264-0"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/OBR.12693"},{"key":"e_1_2_11_63_1","unstructured":"WHO. (2000). Obesity: Preventing and Managing the Global Epidemic. (WHO Obesity Technical Report Series No. 894). World Health Organization.https:\/\/iris.who.int\/handle\/10665\/42330."},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06752"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBALIP.2021.159106"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365-3016.2004.00553.X"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1507\/ENDOCRJ.EJ14-0163"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvac019"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJERPH20032102"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PREGHY.2018.09.004"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2022.951871"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/IJE\/DYY285"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.6407"}],"container-title":["Maternal &amp; Child Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mcn.70086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:40:59Z","timestamp":1758634859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mcn.70086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/mcn.70086"],"URL":"https:\/\/doi.org\/10.1111\/mcn.70086","archive":["Portico"],"relation":{},"ISSN":["1740-8695","1740-8709"],"issn-type":[{"type":"print","value":"1740-8695"},{"type":"electronic","value":"1740-8709"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70086"}}