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NER\u2044T\u2044S\u20442002\u204400189"],"award-info":[{"award-number":["grant no. NER\u2044T\u2044S\u20442002\u204400189"]}]},{"name":"Post-Genomics and Proteomics","award":["grant no. NE\u2044D000580\u20441"],"award-info":[{"award-number":["grant no. NE\u2044D000580\u20441"]}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When domesticated species are not reproductively isolated from their wild relatives, the opportunity arises for artificially selected variants to be re\u2010introduced into the wild. However, the evolutionary consequences of introgression of domesticated genes back into the wild are poorly understood. By combining high\u2010throughput genotyping with 25\u00a0years of long\u2010term ecological field data, we describe the occurrence and consequences of admixture between a primitive sheep breed, the free\u2010living <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>oay sheep of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>t <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ilda, and more modern breeds. Utilizing data from a 50\u00a0K ovine <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> chip, together with forward simulations of demographic scenarios, we show that admixture occurred between Soay sheep and a more modern breed, consistent with historical accounts, approximately 150\u00a0years ago. Haplotype\u2010sharing analyses with other breeds revealed that polymorphisms in coat colour and pattern in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>oay sheep arose as a result of introgression of genetic variants favoured by artificial selection. Because the haplotypes carrying the causative mutations are known to be under natural selection in free\u2010living <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>oay sheep, the admixture event created an opportunity to observe the outcome of a \u2018natural laboratory\u2019 experiment where ancestral and domesticated genes competed with each other. The haplotype carrying the domesticated light coat colour allele was favoured by natural selection, while the haplotype associated with the domesticated self coat pattern allele was associated with decreased survival. Therefore, we demonstrate that introgression of domesticated alleles into wild populations can provide a novel source of variation capable of generating rapid evolutionary changes.<\/jats:p>","DOI":"10.1111\/mec.12378","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T18:14:43Z","timestamp":1371752083000},"page":"4210-4221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Introgression and the fate of domesticated genes in a wild mammal population"],"prefix":"10.1111","volume":"22","author":[{"given":"Philine G. 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UK"},{"name":"The University of Queensland Diamantina Institute Brisbane QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine M.","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Institute of Evolutionary Biology School of Biological Sciences University of Edinburgh Edinburgh EH9 3JT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon.","family":"Slate","sequence":"additional","affiliation":[{"name":"Department of Animal and Plant Sciences University of Sheffield Sheffield S10 2TN 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