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Parasitoids introduce a variety of factors into hosts to promote parasitism, including symbiotic viruses, venom, teratocytes and wasp larvae. Polydnavirus\u2010carrying wasps use viruses to globally suppress host immunity and prevent rejection of developing parasites. Although prior results provide detailed insights into the genes viruses deliver to hosts, little is known about other products. <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>seq and proteomics were used to characterize the proteins secreted by venom glands, teratocytes and larvae from <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>icroplitis demolitor,<\/jats:italic> which carries <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0demolitor<\/jats:italic> bracovirus (Md<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>). These data revealed that venom glands and teratocytes secrete large amounts of a small number of products relative to ovaries and larvae. Venom and teratocyte products exhibited almost no overlap with one another or Md<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> genes, which suggested that <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0demolitor<\/jats:italic> effector molecules are functionally partitioned according to their source. This finding was well illustrated in the case of Md<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content> and teratocytes. Many viral proteins have immunosuppressive functions that include disruption of antimicrobial peptide production, yet this study showed that teratocytes express high levels of the antimicrobial peptide hymenoptaecin, which likely compensates for Md<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\u2010mediated immunosuppression. A second key finding was the prevalence of duplications among genes encoding venom and teratocyte molecules. Several of these gene families share similarities with proteins from other species, while also showing specificity of expression in venom glands or teratocytes. Overall, these results provide the first comprehensive analysis of the proteins a polydnavirus\u2010carrying wasp introduces into its host.<\/jats:p>","DOI":"10.1111\/mec.12648","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T03:41:57Z","timestamp":1388720517000},"page":"890-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Systematic analysis of a wasp parasitism arsenal"],"prefix":"10.1111","volume":"23","author":[{"given":"Gaelen R.","family":"Burke","sequence":"first","affiliation":[{"name":"Department of Entomology University of Georgia 120 Cedar St, 420 Biological Sciences Building Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Entomology University of Georgia 120 Cedar St, 420 Biological Sciences Building Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-120709-144849"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2002.00356.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(03)00116-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1128\/JVI.79.3.1861-1870.2005","article-title":"Glc1.8 from Microplitis demolitor bracovirus induces a loss of adhesion and phagocytosis in insect high five and S2 cells","volume":"79","author":"Beck MH","year":"2005","journal-title":"Journal of Virology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708056104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166788"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.032680-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002722"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06434-11"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects3010091"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003348"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2012.10.020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2008.11.013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2013.03.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1570-7458.2006.00514.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2008.00802.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2003.00439.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-12-r183"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2012.12.010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-5-113"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr367"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/9780691207025"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064125"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2005.05.010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2009.00914.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1883"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09583157.2012.731497"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00820.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.04.080"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0051"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:30:2:109"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1910(02)00054-9"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064432"},{"key":"e_1_2_6_35_1","article-title":"Defensive microbial symbionts in Hymenoptera","author":"Kaltenpoth M","year":"2013","journal-title":"Functional Ecology"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.49.072103.120132"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3106-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801593200"},{"key":"e_1_2_6_40_1","unstructured":"MaddisonWP MaddisonDR(2011)Mesquite: a modular system for evolutionary analysis. 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