{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:35:31Z","timestamp":1780983331081,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":274,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation, GACR","doi-asserted-by":"crossref","award":["P303-11-1398"],"award-info":[{"award-number":["P303-11-1398"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>The protozoan parasite <jats:italic>Toxoplasma gondii<\/jats:italic> is known to induce specific behavioural changes in its intermediate hosts, including humans, that are believed to increase the chance of its successful transmission to the definitive host, the cat. The most conspicuous change is the so\u2010called fatal attraction phenomenon, the switch from the mice's and rats\u2019 natural fear of the smell of cats toward an attraction to this smell. The mechanism of this manipulation activity is unknown; however, many indices suggest that changes in the concentrations of dopamine and testosterone are involved. In this issue of Molecular Ecology, Hari Dass &amp; Vyas (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#mec13006-bib-0010\"\/>) present results of a study showing that, by hypomethylation of certain regulatory elements of key gene, <jats:italic>Toxoplasma<\/jats:italic> is able to reprogramme the brain's genetic machinery in such a way that cat odour activates and changes the wiring of the medial amygdala circuits responsible for sexual behaviour. This study delivers the first clear evidence of a parasite's ability to use sophisticated epigenetic engineering techniques for the manipulation of the phenotype of its infected host.<\/jats:p>","DOI":"10.1111\/mec.13006","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T21:50:23Z","timestamp":1419371423000},"page":"5934-5936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Masterpiece of epigenetic engineering \u2013 how <i>Toxoplasma gondii<\/i> reprogrammes host brains to change fear to sexual attraction"],"prefix":"10.1111","volume":"23","author":[{"given":"Jaroslav","family":"Flegr","sequence":"first","affiliation":[{"name":"Biology Section Faculty of Science Charles University Prague 204004 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Marko\u0161","sequence":"additional","affiliation":[{"name":"Biology Section Faculty of Science Charles University Prague 204004 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1182"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3594"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/489052a"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.073635"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(03)00075-9"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182007004064"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001389"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2014.05.019"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004801"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/489208b"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.12888"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12031"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2012.07.001"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.12042"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023866"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006000886"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2341"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608310104"}],"container-title":["Molecular Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmec.13006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.13006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:34:59Z","timestamp":1696462499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mec.13006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":18,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/mec.13006"],"URL":"https:\/\/doi.org\/10.1111\/mec.13006","archive":["Portico"],"relation":{},"ISSN":["0962-1083","1365-294X"],"issn-type":[{"value":"0962-1083","type":"print"},{"value":"1365-294X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}