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How these environmental shifts are regulated from a metabolic and physiological standpoint, however, still remain to be fully elucidated. We examined the transcriptomic response of\n                    <jats:italic>Schistocephalus solidus<\/jats:italic>\n                    , a trophically transmitted parasite with a complex life cycle, over the course of its development in an intermediate host, the threespine stickleback, and the final avian host. Results from our differential gene expression analysis show major reprogramming events among developmental stages. The final host stage is characterized by a strong activation of reproductive pathways and redox homoeostasis. The attainment of infectivity in the fish intermediate host\u2014which precedes sexual maturation in the final host and is associated with host behaviour changes\u2014is marked by transcription of genes involved in neural pathways and sensory perception. Our results suggest that un\u2010annotated and\n                    <jats:italic>S.\u00a0solidus<\/jats:italic>\n                    \u2010specific genes could play a determinant role in host\u2013parasite molecular interactions required to complete the parasite's life cycle. Our results permit future comparative analyses to help disentangle species\u2010specific patterns of infection from conserved mechanisms, ultimately leading to a better understanding of the molecular control and evolution of complex life cycles.\n                  <\/jats:p>","DOI":"10.1111\/mec.13970","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T09:42:36Z","timestamp":1482226956000},"page":"1118-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Major host transitions are modulated through transcriptome\u2010wide reprogramming events in\n                    <i>Schistocephalus solidus<\/i>\n                    , a threespine stickleback parasite"],"prefix":"10.1111","volume":"26","author":[{"given":"Fran\u00e7ois Olivier","family":"H\u00e9bert","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biologie Institut de Biologie Int\u00e9grative et des Syst\u00e8mes (IBIS) Universit\u00e9 Laval 1030 avenue de la M\u00e9decine Qu\u00e9bec QC G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grambauer","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology and Behaviour University of Leicester Adrian Building University Road Leicester LE1 7RH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology and Behaviour University of Leicester Adrian Building University Road Leicester LE1 7RH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Landry","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie Institut de Biologie Int\u00e9grative et des Syst\u00e8mes (IBIS) Universit\u00e9 Laval 1030 avenue de la M\u00e9decine Qu\u00e9bec QC G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Aubin\u2010Horth","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie Institut de Biologie Int\u00e9grative et des Syst\u00e8mes (IBIS) Universit\u00e9 Laval 1030 avenue de la M\u00e9decine Qu\u00e9bec QC G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.073601"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073403"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.2014.84"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.09.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991466"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002002925"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1163\/1568539042948231"},{"key":"e_1_2_8_9_1","first-page":"121","article-title":"Energy metabolism and infection in helminths","volume":"15","author":"Barrett J","year":"1977","journal-title":"Symposia of the British Society for Parasitology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(79)90050-X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/668592"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(68)90087-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1954.tb07782.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00930961"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Corset: enabling differential gene expression analysis for de novo assembled transcriptomes","volume":"15","author":"Davidson NM","year":"2014","journal-title":"Genome Biology"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.08.011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.12.013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)00605-2"},{"key":"e_1_2_8_19_1","unstructured":"H\u00e9bertFO(2016a)Bulk codes for RNA\u2010seq analysis.Zenodo. doi:10.5281\/zenodo.60211."},{"key":"e_1_2_8_20_1","unstructured":"H\u00e9bertFO(2016b)corset_pipeline: First complete release.Github. doi:10.5281\/zenodo.50971."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.ew9bfh6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-016-0128-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5524\/100197"},{"key":"e_1_2_8_24_1","unstructured":"HennigtC(2015)fpc: Flexible procedures for clustering. 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