{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:07:57Z","timestamp":1792332477122,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["278433"],"award-info":[{"award-number":["278433"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["206298\/Z\/17\/Z"],"award-info":[{"award-number":["206298\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["BSV3\u20100019"],"award-info":[{"award-number":["BSV3\u20100019"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds","doi-asserted-by":"publisher","award":["OT\/14\/115"],"award-info":[{"award-number":["OT\/14\/115"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G066215N"],"award-info":[{"award-number":["G066215N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0D5117N"],"award-info":[{"award-number":["G0D5117N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0B9317N"],"award-info":[{"award-number":["G0B9317N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent years have seen the extensive use of phylogeographic approaches to unveil the dispersal history of virus epidemics. Spatially explicit reconstructions of viral spread represent valuable sources of lineage movement data that can be exploited to investigate the impact of underlying environmental layers on the dispersal of pathogens. Here, we performed phylogeographic inference and applied different post hoc approaches to analyse a new and comprehensive data set of viral genomes to elucidate the dispersal history and dynamics of rabies virus (RABV) in Iran, which have remained largely unknown. We first analysed the association between environmental factors and variations in dispersal velocity among lineages. Second, we present, test and apply a new approach to study the link between environmental conditions and the dispersal direction of lineages. The statistical performance (power of detection, false\u2010positive rate) of this new method was assessed using simulations. We performed phylogeographic analyses of RABV genomes, allowing us to describe the large diversity of RABV in Iran and to confirm the cocirculation of several clades in the country. Overall, we estimate a relatively high lineage dispersal velocity, similar to previous estimates for dog rabies virus spread in northern Africa. Finally, we highlight a tendency for RABV lineages to spread in accessible areas associated with high human population density. Our analytical workflow illustrates how phylogeographic approaches can be used to investigate the impact of environmental factors on several aspects of viral dispersal dynamics.<\/jats:p>","DOI":"10.1111\/mec.15222","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T01:45:14Z","timestamp":1567561514000},"page":"4335-4350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Using phylogeographic approaches to analyse the dispersal history, velocity and direction of viral lineages\u00a0\u2014\u00a0Application to rabies virus spread in Iran"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-1052","authenticated-orcid":false,"given":"Simon","family":"Dellicour","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Rega Institute Laboratory for Clinical and Epidemiological Virology KU Leuven Leuven Belgium"},{"name":"Spatial Epidemiology Lab (SpELL) Universit\u00e9 Libre de Bruxelles Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Troupin","sequence":"additional","affiliation":[{"name":"Unit Lyssavirus Epidemiology and Neuropathology WHO Collaborating Centre for Reference and Research on Rabies Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Jahanbakhsh","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Rabies Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Infectious Diseases Faculty of Veterinary Medicine University of Sadat City Sadat City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Massoudi","sequence":"additional","affiliation":[{"name":"Department of Environment Wildlife Diseases Group Wildlife Bureau Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madjid K.","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Environment Wildlife Diseases Group Wildlife Bureau Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-7732","authenticated-orcid":false,"given":"Guy","family":"Baele","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Rega Institute Laboratory for Clinical and Epidemiological Virology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-5353","authenticated-orcid":false,"given":"Philippe","family":"Lemey","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Rega Institute Laboratory for Clinical and Epidemiological Virology KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Gholami","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Rabies Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-5589","authenticated-orcid":false,"given":"Herv\u00e9","family":"Bourhy","sequence":"additional","affiliation":[{"name":"Unit Lyssavirus Epidemiology and Neuropathology WHO Collaborating Centre for Reference and Research on Rabies Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syr100"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.08.009"},{"key":"e_1_2_8_4_1","first-page":"797","article-title":"Prevention of human rabies; treatment of persons bitten by rabid wolves in Iran","volume":"10","author":"Baltazard M.","year":"1954","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700741104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-10-2545"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005525"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.14470"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9531.112682"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003772"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.921570"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2013.07.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005421"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2016.06.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03763-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw384"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx176"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-0924-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vey023"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01386390"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.04.087"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139095112"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00103"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049475514528174"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5812\/archcid.18773"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0142"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2013.03.051"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss265"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/414716a"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2540.2001.00895.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003709"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-294X.2003.02051.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003569"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184831"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.0919"},{"key":"e_1_2_8_36_1","first-page":"207","article-title":"Epidemiology and control of rabies in Iran","volume":"131","author":"Janani A. R.","year":"2008","journal-title":"Developments in Biologicals"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033579"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476572"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065973"},{"key":"e_1_2_8_40_1","first-page":"360","article-title":"Re\u2010evaluating the burden of rabies in Africa and Asia","volume":"83","author":"Knobel D. L.","year":"2005","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.08.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082348"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13887"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001388"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000520"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msq067"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030392"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vex038"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.032748-0"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2006.tb00500.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.10.026"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880300863X"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002560"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2017.03.005"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206598109"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2014.2878"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syy032"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.11.035"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2007.1041"},{"key":"e_1_2_8_61_1","first-page":"43","article-title":"The rabies situation in the Middle East","volume":"131","author":"Seimenis A.","year":"2008","journal-title":"Developments in Biologicals"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606587113"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vey016"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.007765-0"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001166"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.12728"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006041"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vev016"},{"key":"e_1_2_8_69_1","first-page":"203","article-title":"Oral vaccination of foxes against rabies in Turkey between 2008 and 2010","volume":"125","author":"Un H.","year":"2012","journal-title":"Berliner Und Munchener Tierarztliche Wochenschrift"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-012-0866-y"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189998"},{"key":"e_1_2_8_72_1","volume-title":"0 by 30 our catalytic response","author":"WHO","year":"2018"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-017-0769-6"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6984"}],"container-title":["Molecular Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.15222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mec.15222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.15222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:44:47Z","timestamp":1694180687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mec.15222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":73,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/mec.15222"],"URL":"https:\/\/doi.org\/10.1111\/mec.15222","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736640641.793578885","asserted-by":"object"}]},"ISSN":["0962-1083","1365-294X"],"issn-type":[{"value":"0962-1083","type":"print"},{"value":"1365-294X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2018-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}