{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:43:31Z","timestamp":1789008211749,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["244164"],"award-info":[{"award-number":["244164"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["248792"],"award-info":[{"award-number":["248792"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Domestication of animals imposes strong targeted selection for desired traits but can also result in unintended selection due to new domestic environments. Atlantic salmon (\n                    <jats:italic>Salmo salmar<\/jats:italic>\n                    ) was domesticated in the 1970s and has subsequently been selected for faster growth in systematic breeding programmes. More recently, salmon aquaculture has replaced fish oils (FOs) with vegetable oils (VOs) in feed, radically changing the levels of essential long\u2010chain polyunsaturated fatty acids (LC\u2010PUFAs). Our aim here was to study the impact of domestication on metabolism and explore the hypothesis that the shift to VO diets has unintentionally selected for a domestication\u2010specific lipid metabolism. We conducted a 96\u2010day feeding trial of domesticated and wild salmon fed diets based on FOs, VOs or phospholipids, and compared transcriptomes and fatty acids in tissues involved in lipid absorption (pyloric caeca) and lipid turnover and synthesis (liver). Domesticated salmon had faster growth and higher gene expression in glucose and lipid metabolism compared to wild fish, possibly linked to differences in regulation of circadian rhythm pathways. Only the domesticated salmon increased expression of LC\u2010PUFA synthesis genes when given VOs. This transcriptome response difference was mirrored at the physiological level, with domesticated salmon having higher LC\u2010PUFA levels but lower 18:3n\u20103 and 18:2n\u20106 levels. In line with this, the VO diet decreased growth rate in wild but not domesticated salmon. Our study revealed a clear impact of domestication on transcriptomic regulation linked to metabolism and suggests that unintentional selection in the domestic environment has resulted in evolution of stronger compensatory mechanisms to a diet low in LC\u2010PUFAs.\n                  <\/jats:p>","DOI":"10.1111\/mec.15446","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T05:39:57Z","timestamp":1586929197000},"page":"1860-1872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparative transcriptomics reveals domestication\u2010associated features of Atlantic salmon lipid metabolism"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-8397","authenticated-orcid":false,"given":"Yang","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Biology NTNU Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf Erik","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Biology NTNU Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Nelson","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences Norwegian University of Life Sciences \u00c5s Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u2010Ann","family":"\u00d8stensen","sequence":"additional","affiliation":[{"name":"Department of Biology NTNU Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshuai","family":"Li","sequence":"additional","affiliation":[{"name":"BioMar AS Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Santi","sequence":"additional","affiliation":[{"name":"AquaGen AS Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Vadstein","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Science NTNU Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atle Magnar","family":"Bones","sequence":"additional","affiliation":[{"name":"Department of Biology NTNU Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7778-4515","authenticated-orcid":false,"given":"Jon Olav","family":"Vik","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences Norwegian University of Life Sciences \u00c5s Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-5311","authenticated-orcid":false,"given":"Simen R\u00f8d","family":"Sandve","sequence":"additional","affiliation":[{"name":"Department of Animal and Aquacultural Sciences Norwegian University of Life Sciences \u00c5s Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngvar","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Biology NTNU Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0044\u20108486(94)90319\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106739"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102164\u201015\u2010884"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516004396"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102109.2009.02190.x"},{"key":"e_1_2_9_7_1","volume-title":"Lipid analysis","author":"Christie W. 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