{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:36:27Z","timestamp":1791387387296,"version":"4.3.3"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006318","name":"Universidad Carlos III de Madrid","doi-asserted-by":"publisher","award":["PRIMUS\/SCI\/46"],"award-info":[{"award-number":["PRIMUS\/SCI\/46"]}],"id":[{"id":"10.13039\/501100006318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["17\u201022604S"],"award-info":[{"award-number":["17\u201022604S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Organisms have evolved various mechanisms to cope with the differences in the gene copy numbers between sexes caused by degeneration of Y and W sex chromosomes. Complete dosage compensation or at least expression balance between sexes has been reported predominantly in XX\/XY systems, but rarely in ZZ\/ZW systems. However, this often\u2010reported pattern is based on comparisons of lineages where sex chromosomes evolved from nonhomologous genomic regions, potentially differing in sensitivity to differences in gene copy numbers. Here we document that two reptilian lineages (XX\/XY iguanas and ZZ\/ZW softshell turtles), which independently co\u2010opted the same ancestral genomic region for the function of sex chromosomes, evolved different gene dose regulatory mechanisms. The independent co\u2010option of the same genomic region for the role of sex chromosomes as in the iguanas and the softshell turtles offers great opportunity for testing evolutionary scenarios on sex chromosome evolution under the explicit control of the genomic background and gene identity. We show that the parallel loss of functional genes from the Y chromosome of the green anole and the W chromosome of the Florida softshell turtle led to different dosage compensation mechanisms. Our approach controlling for genetic background thus does not support that the variability in the regulation of gene dose differences is a consequence of ancestral autosomal gene content.<\/jats:p>","DOI":"10.1111\/mec.15853","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T10:17:48Z","timestamp":1613729868000},"page":"1836-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evolution of dosage compensation does not depend on genomic background"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8429-5680","authenticated-orcid":false,"given":"Michail","family":"Rovatsos","sequence":"first","affiliation":[{"name":"Department of Ecology Faculty of Science Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3515-729X","authenticated-orcid":false,"given":"Luk\u00e1\u0161","family":"Kratochv\u00edl","sequence":"additional","affiliation":[{"name":"Department of Ecology Faculty of Science Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz196"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10390"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2017.11.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_7_6_1","volume-title":"FastQC: A quality control tool for high throughput sequence data","author":"Andrews S.","year":"2010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001899"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.17.120183.002021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-014-0478-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.02.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11040416"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"a019406","DOI":"10.1101\/cshperspect.a019406","article-title":"Dosage compensation in mammals","volume":"7","author":"Brockdorff T.","year":"2015","journal-title":"Cold Spring Harbour Perspectives in Biology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol130"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800697"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(19980801)281:5<457::AID-JEZ10>3.0.CO;2-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx064"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.948"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.036871"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13591"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02553-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11070787"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1883"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evx154"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx190"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz053"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12156"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000227837"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts199"},{"key":"e_1_2_7_32_1","volume-title":"Sex chromosome evolution among amniotes: Is the origin of sex chromosomes non\u2010random?","author":"Kratochv\u00edl L.","year":"2021"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.03.005"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2013.07.005"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2009.00853.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.223727.117"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz001"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"11866","DOI":"10.1073\/pnas.1900437116","article-title":"Why haploinsufficiency persists","volume":"116","author":"Morrill S. A.","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/3.5.422"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8720"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001308"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.230433.117"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046854"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2019.0498"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04267-9"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88178-7"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2016.05.010"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508454112"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1499-6"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116763109"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35684"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evz133"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.251207.119"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0418-y"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.114.014084"},{"key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000490124","article-title":"Triploid colubrid snake provides insight into the mechanism of sex determination in advanced snakes","volume":"12","author":"Rovatsos M.","year":"2018","journal-title":"Sexual Development"},{"key":"e_1_2_7_57_1","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2020.0102","volume-title":"Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos","author":"Rovatsos M.","year":"2021"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2013.1093"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42150"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msz024"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13635"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.2016.18"},{"key":"e_1_2_7_63_1","first-page":"231","article-title":"Evolution of dosage compensation in Anolis carolinensis, a reptile with XX\/XY chromosomal sex determination","volume":"9","author":"Rupp S. M.","year":"2017","journal-title":"Genome Biology and Evolution"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08298"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000050"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10577-009-9053-y"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001643"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2615"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201100091"},{"key":"e_1_2_7_70_1","first-page":"33","article-title":"Sexual differentiation in hatching loggerheads (Caretta caretta) incubated at different controlled temperatures","volume":"36","author":"Yntema C. L.","year":"1980","journal-title":"Herpetologica"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-4015-4_3"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2007.02.002"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evw075"}],"container-title":["Molecular Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.15853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mec.15853","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.15853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:00:22Z","timestamp":1693544422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mec.15853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/mec.15853"],"URL":"https:\/\/doi.org\/10.1111\/mec.15853","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.14.251801","asserted-by":"object"}]},"ISSN":["0962-1083","1365-294X"],"issn-type":[{"value":"0962-1083","type":"print"},{"value":"1365-294X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"2020-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}