{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:44:10Z","timestamp":1775508250916,"version":"3.50.1"},"reference-count":86,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The takin (<jats:italic>Budorcas taxicolor<\/jats:italic>) is one of the largest bovid herbivores in the subfamily Caprinae. The takin is at high risk of extinction, but its taxonomic status and genetic diversity remain unclear. In this study, we constructed the first reference genome of <jats:italic>Bu<\/jats:italic>. <jats:italic>taxicolor<\/jats:italic> using PacBio long High\u2010Fidelity reads and Hi\u2010C technology. The assembled genome is ~2.95\u00a0Gb with a contig N50 of 68.05\u00a0Mb, which were anchored onto 25+XY chromosomes. We found that the takin was more closely related to muskox than to other Caprinae species. Compared to the common ancestral karyotype of bovidae (2<jats:italic>n<\/jats:italic>\u00a0=\u00a060), we found the takin (2<jats:italic>n<\/jats:italic>\u00a0=\u00a052) experienced four chromosome fusions and one large translocation. Furthermore, we resequenced nine golden takins from the main distribution area, the Qinling Mountains, and identified 3.3\u00a0million single nucleotide polymorphisms. The genetic diversity of takin was very low (<jats:italic>\u03b8\u03c0<\/jats:italic>\u00a0=\u00a00.00028 and heterozygosity\u00a0=0.00038), among the lowest detected in domestic and wild mammals. Takin genomes showed a high inbreeding coefficient (FROH\u00a0=0.217), suggesting severe inbreeding depression. The demographic history showed that the effective population size of takins declined significantly from ~100,000\u00a0years ago. Our results provide valuable information for protection of takins and insights into their evolution.<\/jats:p>","DOI":"10.1111\/mec.16483","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T12:29:27Z","timestamp":1650889767000},"page":"1323-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chromosome\u2010level genome assembly for takin (<i>Budorcas taxicolor<\/i>) provides insights into its taxonomic status and genetic diversity"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-161X","authenticated-orcid":false,"given":"Anning","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qimeng","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Center for Ruminant Genetic and Evolution Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Center for Ruminant Genetic and Evolution Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelei","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Center for Ruminant Genetic and Evolution Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keli","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghu","family":"Lei","sequence":"additional","affiliation":[{"name":"Research Center for the Qinling Giant Panda (Shaanxi Rare Wildlife Rescue Base) Shaanxi Academy of Forestry Sciences  Zhouzhi Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangsheng","family":"Jia","sequence":"additional","affiliation":[{"name":"Research Center for the Qinling Giant Panda (Shaanxi Rare Wildlife Rescue Base) Shaanxi Academy of Forestry Sciences  Zhouzhi Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4821-3585","authenticated-orcid":false,"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Center for Ruminant Genetic and Evolution Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linsen","family":"Zan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Research Center for the Qinling Giant Panda (Shaanxi Rare Wildlife Rescue Base) Shaanxi Academy of Forestry Sciences  Zhouzhi Shaanxi 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