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IAV outbreaks occur in the Northwest Atlantic, but grey seals (<jats:styled-content style=\"fixed-case\"><jats:italic>Halichoerus grypus<\/jats:italic><\/jats:styled-content>) appear to be less susceptible to IAV compared to other species. The subclinical nature of IAV infection in addition to life history factors suggest grey seals are a potential wild reservoir host for IAV. We investigated differential gene expression among grey seals naturally exposed to IAV to elucidate genetic mechanisms involved in grey seal disease resistance. RNA sequencing was conducted on blood samples (<jats:italic>N<\/jats:italic>\u2009=\u200931) collected from grey seal pups in Massachusetts, US between 2014 and 2019. Samples were grouped for analysis based on presence\/absence of viral RNA and antibodies. In the presence of IAV RNA, we observed widespread down\u2010regulation of genes, including immune genes, potentially as a result of IAV\u2010induced host shutoff. 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