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Understanding its adaptation to such extreme conditions provides key insights into survival strategies under fluctuating oxygen availability. We investigated the transcriptomic and metabolomic responses of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. capensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    under normoxia, hypoxia, and recovery, focusing on the gills and digestive gland. Our findings highlight distinct organ\u2010specific responses, with the gills showing strong transcriptional changes to oxygen fluctuations, in contrast to the more stable profile observed in the digestive gland. Under hypoxic conditions, the gills exhibited coordinated downregulation of protein synthesis, transposable element activity, and immune function, suggesting a tightly regulated energy conservation strategy and mechanisms to preserve symbiont stability and genomic integrity. Activation of prokaryotic metabolism in the gills supports the symbionts' role in host energy acquisition and sulfide detoxification during hypoxia. In contrast, the digestive gland showed minimal transcriptional shifts during anoxia, with upregulation of pathways supporting structural maintenance. Upon reoxygenation, the gills displayed an active and asymmetric recovery, characterised by rapid restoration of protein synthesis and gradual normalisation of protein degradation and immune functions. Despite significant transcriptomic changes, the metabolome remained largely stable, reflecting\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. capensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    's resilience to oxygen fluctuations. However, an overshoot in TCA cycle intermediates and derepression of previously downregulated pathways indicate that reoxygenation involves active metabolic reprogramming, not merely a return to baseline. This study highlights the specialised tissue responses and symbiotic contributions that enable\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. capensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    to thrive in one of the ocean's most challenging environments.\n                  <\/jats:p>","DOI":"10.1111\/mec.70194","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:21:12Z","timestamp":1764656472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unravelling Hypoxia Tolerance: Transcriptomic and Metabolic Insights From\n                    <i>Lucinoma capensis<\/i>\n                    in an Oxygen Minimum Zone"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-4302","authenticated-orcid":false,"given":"Inna M.","family":"Sokolova","sequence":"first","affiliation":[{"name":"Department of Marine Biology, Institute for Biological Sciences University of Rostock  Rostock Germany"},{"name":"Department of Maritime Systems, Interdisciplinary Faculty University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene P.","family":"Sokolov","sequence":"additional","affiliation":[{"name":"Department of Marine Biology, Institute for Biological Sciences University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Piontkivska","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Kent State University  Kent Ohio USA"},{"name":"Brain Health Research Institute Kent State University  Kent Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Timm","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology, Institute for Biological Sciences University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Amorim","sequence":"additional","affiliation":[{"name":"Department of Biological Oceanography Leibniz Institute for Baltic Sea Research Warnem\u00fcnde  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5437-5495","authenticated-orcid":false,"given":"Michael L.","family":"Zettler","sequence":"additional","affiliation":[{"name":"Department of Biological Oceanography Leibniz Institute for Baltic Sea Research Warnem\u00fcnde  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60261-w"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.243304"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-017-0795-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13571-w"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2021.110617"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecss.2023.108421"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_11_10_1","first-page":"225","volume-title":"Ocean Deoxygenation: Everyone's Problem. 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