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Genome\u2010wide patterns of age\u2010associated hypo\u2010 and hypermethylation have been applied to generate predictive models (i.e., \u201cepigenetic clocks\u201d) capable of estimating chronological age in an increasingly diverse set of species including many mammals, a few birds, a reptile, and several bony fishes. Elasmobranchs (sharks, skates, and rays) are underrepresented in comparative investigations of epigenetic aging despite exhibiting exceptional life history variation, occupying a key basal position in the vertebrate phylogeny, and encompassing a large proportion of threatened species lacking accurate, non\u2010lethal age determination methods. Here, we characterize epigenome\u2010wide aging signals in the zebra shark (\n                    <jats:italic>Stegostoma tigrinum<\/jats:italic>\n                    ), a long\u2010lived elasmobranch of conservation concern, from whole\u2010genome enzymatic methyl\u2010sequencing of whole blood. Using a cohort of 51 known\u2010age aquarium\u2010bred individuals, we develop several epigenetic clock models capable of predicting chronological age with a median absolute error of 1.03\u20131.99\u2009years (3.32%\u20136.42% of lifespan) based on the methylation status of as few as ten cytosines. We further apply our models to 19 individuals of unknown age originating from the wild. By profiling the broader age\u2010associated methylome we demonstrate that these patterns not only predict age with high accuracy but also exhibit striking similarities in their genomic distributions to those observed in mammals pointing to conservation of the processes underlying epigenetic aging across vertebrates.\n                  <\/jats:p>","DOI":"10.1111\/mec.70326","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:16:20Z","timestamp":1775214980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genome\u2010Wide\n                    <scp>DNA<\/scp>\n                    Methylation Patterns Predict Age in the Zebra Shark (\n                    <i>Stegostoma tigrinum<\/i>\n                    ) and Provide Insight Into the Evolution of Vertebrate Aging"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-1490","authenticated-orcid":false,"given":"Samantha L.","family":"Bock","sequence":"first","affiliation":[{"name":"Department of Integrative Biology, W. 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Kellogg Biological Station Michigan State University  Hickory Corners Michigan USA"},{"name":"Savannah River Ecology Laboratory University of Georgia  Aiken South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-4939","authenticated-orcid":false,"given":"Kady","family":"Lyons","sequence":"additional","affiliation":[{"name":"Georgia Aquarium  Atlanta Georgia USA"},{"name":"Department of Marine Sciences University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Florida Museum of Natural History  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-5419","authenticated-orcid":false,"given":"Jennifer","family":"Wyffels","sequence":"additional","affiliation":[{"name":"Marine Science Research Center Ripley's Aquariums  Myrtle Beach South Carolina USA"},{"name":"Delaware Biotechnology Institute University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Adams","sequence":"additional","affiliation":[{"name":"Aquarium of the Pacific  Long Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"Klerks","sequence":"additional","affiliation":[{"name":"Burgers' Zoo  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Jeskie","sequence":"additional","affiliation":[{"name":"Columbus Zoo and Aquarium  Powell Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Leever","sequence":"additional","affiliation":[{"name":"Life Sciences Department Golden Nugget  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Hartl","sequence":"additional","affiliation":[{"name":"Jenkinson's Aquarium  Point Pleasant Beach New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Almunia","sequence":"additional","affiliation":[{"name":"Loro Parque Fundaci\u00f3n  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Peterson","sequence":"additional","affiliation":[{"name":"Minnesota Zoo  Apple Valley Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6641-6995","authenticated-orcid":false,"given":"Ana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Oceanario de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Okinawa Churaumi Aquarium, Okinawa Churashima Foundation  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Archibald","sequence":"additional","affiliation":[{"name":"Omaha's Henry Doorly Zoo and Aquarium  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Spaulding","sequence":"additional","affiliation":[{"name":"Point Defiance Zoo and Aquarium  Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Leyden","sequence":"additional","affiliation":[{"name":"SEA LIFE Kansas City Aquarium  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele A.","family":"Montano","sequence":"additional","affiliation":[{"name":"SeaWorld Parks  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Vasey","sequence":"additional","affiliation":[{"name":"SEA LIFE Carlsbad Aquarium  Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Rowland","sequence":"additional","affiliation":[{"name":"Shark Reef Aquarium at Mandalay Bay  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Watson","sequence":"additional","affiliation":[{"name":"John G. 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