{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:19:54Z","timestamp":1787815194393,"version":"build-2784847793"},"reference-count":84,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2044826"],"award-info":[{"award-number":["2044826"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2526917"],"award-info":[{"award-number":["2526917"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010942","name":"University of North Carolina at Charlotte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Animals rely on diverse molecular mechanisms to maintain beneficial microbial associations while also defending against pathogens, yet the extent to which these responses vary among genotypes of a single species remains poorly understood. Using individuals from different locations of the sea anemone\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Nematostella vectensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , we compared transcriptional responses to a commensal (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vibrio diabolicus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) and pathogen (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vibrio coralliilyticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) bacterium. We find striking genotype\u2010specific divergence: individuals from Nova Scotia mounted a strong transcriptional response to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>V. diabolicus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , whereas the North Carolina and Florida individuals showed almost no response to this same bacterium. In contrast, all individuals regardless of location exhibited a large transcriptional response to the pathogen\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>V. coralliilyticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    . These responses involved key immune pathways (e.g., cGAS\u2010STING, NF\u2010\u03baB, and proteostasis\u2010related stress responses), suggesting that different genotypes deploy distinct molecular responses when encountering the same bacterium. The robust, immune\u2010like response of the individuals from Nova Scotia to a bacterium considered commensal in other populations indicates that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>V. diabolicus<\/jats:italic>\n                    <\/jats:styled-content>\n                    may not function as a commensal across the species range. Such genotype\u2010by\u2010microbe specificity points to potential local adaptation to particular bacterial partners that underscores the complexity of holobiont regulation across heterogeneous environments and stresses the importance of assessing additive, synergistic, and antagonistic interactions across hologenomic mosaics.\n                  <\/jats:p>","DOI":"10.1111\/mec.70517","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:01:56Z","timestamp":1787580116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is a Commensal Here, a Pathogen There? Genotype Specific Responses by the Sea Anemone\n                    <i>Nematostella vectensis<\/i>\n                    to\n                    <i>Vibrio<\/i>\n                    Species"],"prefix":"10.1111","volume":"35","author":[{"given":"Justin","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of North Carolina at Charlotte  Charlotte North Carolina USA"},{"name":"Center for Computational Intelligence to Predict Health and Environmental Risks University of North Carolina at Charlotte  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-2872","authenticated-orcid":false,"given":"Quinton","family":"Krueger","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of North Carolina at Charlotte  Charlotte North Carolina USA"},{"name":"Center for Computational Intelligence to Predict Health and Environmental Risks University of North Carolina at Charlotte  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-184X","authenticated-orcid":false,"given":"Tyler J.","family":"Carrier","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of North Carolina at Charlotte  Charlotte North Carolina USA"},{"name":"Center for Computational Intelligence to Predict Health and Environmental Risks University of North Carolina at Charlotte  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-9294","authenticated-orcid":false,"given":"Yehu","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, Faculty of Science The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-7118","authenticated-orcid":false,"given":"Adam M.","family":"Reitzel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of North Carolina at Charlotte  Charlotte North Carolina USA"},{"name":"Center for Computational Intelligence to Predict Health and Environmental Risks University of North Carolina at Charlotte  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-402"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_11_4_1","unstructured":"Andrews S.2010.\u201cFastQC:A Quality Control Tool for High Throughput Sequence Data.\u201d"},{"key":"e_1_2_11_5_1","unstructured":"Arbizu M.2020.\u201cPairwiseAdonis: Pairwise Multilevel Comparison Using Adonis.\u201dgithub.com\/pmartinezarbizu\/pairwiseAdonis."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2005.00847.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.726795"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001726"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31350-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.7.4236-4242.2003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnab002"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002226"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711530114"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2262"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200797"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3558"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2635"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps07924"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2004.02313.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20181"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01251"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1654-1103.2003.tb02228.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01701-z"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1016097"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1832-y"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.18991.1"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703375104"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2016.00148"},{"key":"e_1_2_11_32_1","article-title":"cJUN Dependent Innate Immunity Controls Microbiome Through Selective Phagocytosis in Nematostella","volume":"17","author":"Fraune S.","year":"2026","journal-title":"Nature Communications"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188265"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0601"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt086"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/1352679"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03800-z"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223490"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10618600.1996.10474713"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4285"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201075511\u2010w"},{"key":"e_1_2_11_42_1","unstructured":"Kolde R.2019.\u201cPheatmap: Pretty Heatmaps.\u201dhttps:\/\/CRAN.R\u2010project.org\/package=pheatmap."},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102218"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.07.022"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.70339"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/mra.01075-23"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/ijm\/4107949"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.5534"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.05.038"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/mra.00069-25"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01474-25"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02013"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.03.032"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/445153a"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218525110"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(00)00147-8"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12926"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2894"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2008.01788.x"},{"key":"e_1_2_11_61_1","article-title":"Host\u2010Microbe Coevolution: Applying Evidence From Model Systems to Complex Marine Invertebrate Holobionts","volume":"10","author":"O'Brien P.","year":"2019","journal-title":"MBio"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186072.114"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps10281"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10530-007-9196-8"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.12228"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12237-009-9231-3"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02930-14"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-020-00855-8"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.70098"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03743-5"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35794-9"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2540"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2004.05.007"},{"key":"e_1_2_11_75_1","article-title":"Heat Shock Proteins and Disease Control in Aquatic Organisms","volume":"2","author":"Sung Y.","year":"2011","journal-title":"Aquaculture Research & Development"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw256"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.1.19"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.14489"},{"key":"e_1_2_11_79_1","first-page":"1","article-title":"A New Evolutionary Law","volume":"1","author":"Van Valen L.","year":"1973","journal-title":"Evolutionary Theory"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2022.1088"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005595"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.147"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi3338"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1540-2"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00123.x"}],"container-title":["Molecular Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.70517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mec.70517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.70517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:59:11Z","timestamp":1787813951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mec.70517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":84,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/mec.70517"],"URL":"https:\/\/doi.org\/10.1111\/mec.70517","archive":["Portico"],"relation":{},"ISSN":["0962-1083","1365-294X"],"issn-type":[{"value":"0962-1083","type":"print"},{"value":"1365-294X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70517"}}