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Unlike vertebrates, which possess a sophisticated immune system, invertebrates rely entirely on innate immunity to combat pathogens. Yet, the molecular underpinnings and life\u2010history consequences of immune activation remain little understood in non\u2010insect invertebrates. Here, we combine life\u2010history trait analysis with transcriptomics to investigate immune responses in an aquatic invertebrate exposed to a natural yeast parasite. By comparing infected, exposed\u2010uninfected, and unexposed individuals, we identified candidate genes potentially involved in haemocyte recruitment and the reinforcement of the gut epithelium. These patterns highlight candidate mechanisms that may contribute to resistance following pathogen exposure. Exposed\u2010uninfected individuals also showed delayed reproductive maturation, though lifetime reproductive output was ultimately maintained. Therefore, this suggests that successful exposure and immunity changes may be associated with a transient shift in reproductive allocation rather than a persistent reduction in reproductive output. In contrast, infected hosts exhibited stronger changes in metabolic and protein biosynthesis processes, consistent with a resource depletion hypothesis. These metabolic shifts align with reduced investment in reproduction, as infection appears to affect the number of offspring produced in the first brood. Our findings provide novel insights into the molecular and life\u2010history responses associated with pathogen exposure and established infection and suggest candidate mechanisms through which host responses may shape life\u2010history strategies in non\u2010insect invertebrates, with broad implications for understanding host\u2013parasite coevolution.<\/jats:p>","DOI":"10.1111\/mec.70543","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:54:30Z","timestamp":1789736070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic Landscape Reveals Immunity Related Trade\u2010Offs in an Invertebrate\u2010Fungal Host\u2013Parasite System"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-0579","authenticated-orcid":false,"given":"Sofia","family":"Paraskevopoulou","sequence":"first","affiliation":[{"name":"School of Zoology, George S. 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