{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:52:14Z","timestamp":1791996734873,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2011109"],"award-info":[{"award-number":["2011109"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Understanding the genetic architecture of pathogen resistance and its relationship to host life\u2010history traits is a fundamental problem in evolutionary biology, yet the conditions under which resistance costs manifest as detectable trade\u2010offs remain poorly understood. Here, we examine resistance in\n                    <jats:italic>Plodia interpunctella<\/jats:italic>\n                    (Indian meal moth) to its granulovirus (PiGV) across 12 inbred lines maintained without deliberate pathogen exposure, alongside an independently assembled outbred stock population as a genomic reference. We quantify resistance using LD50 values from dose\u2013response assays, summarize developmental life\u2010history variation using a composite principal\u2010component axis derived from pupal weight, development time and growth rate, and evaluate genomic structure and window\u2010level associations with resistance. Resistance varied approximately two\u2010fold across inbred lines. Neither the composite life\u2010history axis nor any individual life\u2010history trait was significantly correlated with LD50. In contrast, genomic PC1, the primary axis of CDS\u2010restricted genomic differentiation, was significantly associated with resistance (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.65,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022), whereas overall pairwise distance was not. No individual PCA\u2010LD50 window survived multiple\u2010testing correction; instead, resistance\u2010associated signal was distributed broadly across the genome, and convergent signal spanning five chromosomes showed no enrichment for genes with known immune functions. This pattern is consistent with a diffuse, potentially polygenic basis for resistance, although the modest number of lines limits locus\u2010level inference. Together with prior work demonstrating resistance\u2010growth trade\u2010offs in this system, our results suggest that resistance can be genomically structured without detectable coupling to the developmental life\u2010history variation measured here, and that expression of resistance costs depends on genetic and environmental context.\n                  <\/jats:p>","DOI":"10.1111\/mec.70563","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:12:12Z","timestamp":1790651532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Structure Predicts Granulovirus Resistance Without a Detectable Life\u2010History Trade\u2010Off in\n                    <scp>\n                      <i>Plodia interpunctella<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-3077","authenticated-orcid":false,"given":"P. Signe","family":"White","sequence":"first","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6759-6834","authenticated-orcid":false,"given":"Jonathan","family":"Barajas","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Burnsed","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4153-4051","authenticated-orcid":false,"given":"Noah","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zucel","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Walzer","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-8248","authenticated-orcid":false,"given":"Peter H.","family":"Sudmant","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Boots","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology University of California, Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2004.05.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010022\u201002823\u20107"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.13639"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evo.13623"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/jipa.1993.1053"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010ecolsys\u2010102723\u2010043048"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755\u20100998.13768"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/660833"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2390128"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1999.1009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/303181"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1994.0122"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0962\u20101083.2001.01439.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects12070626"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13769"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/132402"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46440"},{"key":"e_1_2_12_20_1","volume-title":"Introduction to Quantitative Genetics","author":"Falconer D. 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