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In the mosquito\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aedes aegypti<\/jats:italic>\n                    <\/jats:styled-content>\n                    , the forest\u2010associated subspecies\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">Aedes aegypti<\/jats:styled-content>\n                      formosus\n                    <\/jats:italic>\n                    (Aaf) underwent a domestication process approximately 5000\u2009years ago, giving rise to the globally invasive, human\u2010associated arbovirus vector\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">Aedes aegypti<\/jats:styled-content>\n                      aegypti\n                    <\/jats:italic>\n                    (Aaa). Despite extensive human\u2010mediated transport, the two subspecies remain largely distinct, with admixture documented mainly in coastal Africa and Saudi Arabia. We examined Saudi Arabian\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    across climatically contrasting regions \u2013 the humid south and arid west\u2010 using a Saudi Arabian dataset (11,939 SNPs) to examine within\u2010country genetic and environmental variation and a global dataset (13,455 SNPs) to assess ancestry and admixture in a worldwide context. Genomic analyses revealed strong west\u2013south differentiation, with Jazan Highland showing admixture between subspecies and the highest proportion of Aaf ancestry. Multiple pulses of gene flow into and within southern Saudi Arabia suggest Aaf populations act as a reservoir of genetic variation. Genome\u2010wide scans identified a candidate region associated with the humidity gradient, harbouring an elongase of very long\u2010chain fatty acids (AAEL024147), essential for cuticle production and minimizing water loss. Because the Saudi Arabian genetic background is predominantly the arid\u2010adapted subspecies Aaa, the presence of Aaf ancestry at this locus may reflect localized introgression with adaptive relevance under an increasingly humid environment. Our findings highlight how secondary contact between divergent lineages may contribute to local adaptation in\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    , with implications for predicting responses to environmental change.\n                  <\/jats:p>","DOI":"10.1111\/mec.70575","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:23:44Z","timestamp":1791177824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Introgression Shapes Genetic Variation Associated With Humid Environments in\n                    <scp>\n                      <i>Aedes aegypti<\/i>\n                    <\/scp>\n                    Mosquitoes From Saudi Arabia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9735-3501","authenticated-orcid":false,"given":"Abadi M.","family":"Mashlawi","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science Jazan University  Jazan Kingdom of Saudi Arabia"},{"name":"Environment and Nature Research Centre Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-7683","authenticated-orcid":false,"given":"Dario","family":"Balcazar","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology Yale University  New Haven Connecticut USA"},{"name":"Department of Entomology Center for Vector Biology &amp; Zoonotic Diseases, The Connecticut Agricultural Experiment Station  New Haven Connecticut USA"},{"name":"Centro de Estudios Parasitol\u00f3gicos y Vectores (CEPAVE), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Universidad Nacional de La Plata (CCT, CONICET\u2010UNLP)  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4327-5130","authenticated-orcid":false,"given":"Sara A.","family":"Abuelmaali","sequence":"additional","affiliation":[{"name":"1129 Medical Entomology Laboratory, School of Biological Sciences Universiti Sains Malaysia  Penang Malaysia"},{"name":"National Public Health Laboratory Federal Ministry of Health  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-1846","authenticated-orcid":false,"given":"Mohammed Fahad","family":"Albeshr","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed F.","family":"Sallam","sequence":"additional","affiliation":[{"name":"Health Geography and Disease Ecology, Department of Preventive Medicine and Biostatistics Uniformed Service University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-7410","authenticated-orcid":false,"given":"Hesham M.","family":"Al\u2010Mekhlafi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"},{"name":"Department of Parasitology, Faculty of Medicine and Health Sciences Sana'a University  Sana'a Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-7103","authenticated-orcid":false,"given":"Catherine","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Earth and Environmental Sciences, Faculty of Science and Engineering University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-3988","authenticated-orcid":false,"given":"Andrea","family":"Gloria\u2010Soria","sequence":"additional","affiliation":[{"name":"Department of Entomology Center for Vector Biology &amp; 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