{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:50:48Z","timestamp":1791996648233,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470487"],"award-info":[{"award-number":["32470487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201278"],"award-info":[{"award-number":["32201278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["5242016"],"award-info":[{"award-number":["5242016"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Ecology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Seasonal variation in food resources represents a major ecological challenge for wild herbivores, yet how naturally selected dietary resources become associated with host and microbial responses remains poorly understood. During winter, Brandt's voles (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lasiopodomys brandtii<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) cache large amounts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Artemisia frigida<\/jats:italic>\n                    <\/jats:styled-content>\n                    , suggesting that this plant may have ecological significance beyond its nutritional value. However, the biological basis underlying this seasonal food preference remains unclear. Here, using Brandt's voles as a model system, we investigated whether the naturally selected winter food\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. frigida<\/jats:italic>\n                    <\/jats:styled-content>\n                    was associated with coordinated variation in host physiology and gut microbial organization under cold conditions. By integrating physiological phenotyping, hypothalamic neuroendocrine analyses, adipose tissue transcriptomics, shotgun metagenomics and metagenomic binning, we characterized host and microbial responses across multiple biological levels. Dietary\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. frigida<\/jats:italic>\n                    <\/jats:styled-content>\n                    was associated with altered hypothalamic\n                    <jats:italic>AgRP<\/jats:italic>\n                    expression, increased\n                    <jats:italic>UCP1<\/jats:italic>\n                    expression in BAT and transcriptional changes related to lipid metabolism and thermogenic pathways during cold exposure. Supplement of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. frigida<\/jats:italic>\n                    <\/jats:styled-content>\n                    was associated with changes in gut microbial community structure, enrichment of specific bacterial taxa and shifts in predicted microbial functional potential. Genome\u2010resolved analyses further reconstructed 277 non\u2010redundant metagenome\u2010assembled genomes, enabling assessment of microbial ecological variation associated with seasonal food conditions. Together, our findings provide molecular ecological evidence linking winter caching of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009frigida<\/jats:italic>\n                    <\/jats:styled-content>\n                    with coordinated variation in host physiology and gut microbial organization, highlighting seasonal dietary resources as an overlooked component of ecological variation in wildlife.\n                  <\/jats:p>","DOI":"10.1111\/mec.70576","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:06:20Z","timestamp":1790751980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Winter Caching of\n                    <i>Artemisia frigida<\/i>\n                    Is Associated With Host Physiological and Gut Microbial Variation in Brandt's Voles"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6163-2509","authenticated-orcid":false,"given":"Tingbei","family":"Bo","sequence":"first","affiliation":[{"name":"School of Grassland Science Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1982-2671","authenticated-orcid":false,"given":"Xianhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Cambridge\u2010Suda Genomic Resource Center Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-9653","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science Shandong University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Grassland Science Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Grassland Science Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4757-0822","authenticated-orcid":false,"given":"Hangyu","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Grassland Science Beijing Forestry University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4958-6774","authenticated-orcid":false,"given":"Jing","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences Wenzhou University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/1365774"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00219"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396\u2010019\u20100492\u2010y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00188"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065317"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.11.033"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2832"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12405"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo00671a"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7359"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ele.12329"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010019\u20100256\u20108"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22309"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.015"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12240"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2008.02.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj\u2010cs.104"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20104877.2008.00085.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010020\u201003108\u2010w"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8080307"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2017.126"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.186072.114"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010017\u20100012\u20107"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600100195"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3935"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.12.005"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2022.2052086"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.018"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40242\u2010013\u20102295\u20104"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102014\u201015\u20103\u2010r46"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14182719"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmaa104"}],"container-title":["Molecular Ecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.70576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mec.70576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mec.70576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:28:21Z","timestamp":1791995301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/mec.70576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":35,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/mec.70576"],"URL":"https:\/\/doi.org\/10.1111\/mec.70576","archive":["Portico"],"relation":{},"ISSN":["0962-1083","1365-294X"],"issn-type":[{"value":"0962-1083","type":"print"},{"value":"1365-294X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70576"}}