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Theory predicts that such invaders should exhibit reduced genetic diversity and increased inbreeding, which should restrict their evolutionary potential and often lead to inbreeding depression. Here, we provide evidence for an invader succeeding against these odds by demonstrating strikingly strong inbreeding in a highly successful, invasive freshwater mussel. Using whole\u2010genome resequencing data, we show that zebra mussels (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Dreissena polymorpha<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) from thriving invasive populations carry numerous and long runs of homozygosity (ROH) in their genomes, reflecting severe, sequential founder events followed by inbreeding during the invasion process. Additionally, predicted genetic load (accumulation of deleterious mutations) is correlated with inbreeding levels: more inbred invasive populations exhibit lower masked (i.e., heterozygous) but higher realised (i.e., homozygous) load compared to less inbred populations. These genomic consequences of inbreeding would be expected to decrease the fitness of invasives, but here have not prevented their success. Our study thus challenges conventional expectations that inbreeding and high numbers of putatively deleterious alleles should limit biological invasion success. This research provides a compelling example of an invader that defies genetic expectations, and is therefore broadly relevant for understanding invasion success and dynamics across taxa.\n                  <\/jats:p>","DOI":"10.1111\/mec.70584","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:00:57Z","timestamp":1791612057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bottlenecked but Booming: Strong Inbreeding in a Highly Invasive Freshwater Mussel"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6002-2891","authenticated-orcid":false,"given":"Antti","family":"Miettinen","sequence":"first","affiliation":[{"name":"Department of Biology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Sejrskild","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-4333","authenticated-orcid":false,"given":"Carol A.","family":"Stepien","sequence":"additional","affiliation":[{"name":"Center for Global Change and Earth Observations, Michigan State University  East Lansing Michigan USA"},{"name":"Carolina Environmental and DNA Analytics, LLC  Castle Hayne North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-4828","authenticated-orcid":false,"given":"Michael M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Biology Aarhus University  Aarhus 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