{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:43:36Z","timestamp":1790649816342,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Polycystic kidney disease (\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      ) is a common cause of end\u2010stage renal failure and many of these patients suffer vascular dysfunction and hypertension. It remains unclear whether\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      is associated with abnormal microvascular structure. Thus, this study examined the renovascular structure in\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      rats (\n                      <jats:styled-content style=\"fixed-case\">PCK<\/jats:styled-content>\n                      model) and controls were studied at 10\u00a0weeks of age, and mean arterial pressure (\n                      <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n                      ), renal blood flow, and creatinine clearance were measured. Microvascular architecture and cyst number and volume were assessed using micro\u2010computed tomography, and angiogenic pathways evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with controls,\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      animals had an increase in\n                      <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\n                      (126.4\u00a0\u00b1\u00a04.0 vs. 126.2\u00a0\u00b1\u00a02.7\u00a0mmHg) and decreased clearance of creatinine (0.39\u00a0\u00b1\u00a00.09 vs. 0.30\u00a0\u00b1\u00a00.05\u00a0mL\/min), associated with a decrease in microvascular density, both in the cortex (256\u00a0\u00b1\u00a022 vs. 136\u00a0\u00b1\u00a020 vessels per cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and medullar (114\u00a0\u00b1\u00a014 vs. 50\u00a0\u00b1\u00a09 vessels\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and an increase in the average diameter of glomeruli (104.14\u00a0\u00b1\u00a02.94 vs. 125.76\u00a0\u00b1\u00a09.06\u00a0mm).\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      animals had increased fibrosis (2.2\u00a0\u00b1\u00a00.2 fold vs. control) and a decrease in the cortical expression in hypoxia inducible factor 1\u2010\u03b1 and vascular endothelial growth factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      animals have impaired renal vascular architecture, which can have significant functional consequences. The\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      microvasculature could represent a therapeutic target to decrease the impact of this disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.12022","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:11:53Z","timestamp":1353456713000},"page":"183-189","source":"Crossref","is-referenced-by-count":35,"title":["Polycystic Kidneys Have Decreased Vascular Density: A Micro\u2010CT Study"],"prefix":"10.1111","volume":"20","author":[{"given":"Rende","family":"Xu","sequence":"first","affiliation":[{"name":"Divisions of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Franchi","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Miller","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Crane","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Psaltis","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rodriguez\u2010Porcel","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Diseases Department of Internal Medicine Mayo Clinic Rochester Minnesota 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