{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:46:02Z","timestamp":1791189962371,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>G\u2010CSF<\/jats:styled-content> and EPO<\/jats:styled-content> have shown a notable capability in neovascularization. However, their use is limited because of untoward leucocytosis, erythrogenesis, and short half\u2010life in the plasma. Herein, we examined whether G\u2010CSF<\/jats:styled-content> and EPO<\/jats:styled-content> released from fibrin gel injected into ischemic tissues would synergistically promote neovascularization with limited systematic effects in a rat hindlimb ischemic model.<\/jats:p><\/jats:sec>Methods and Results<\/jats:title>In vivo<\/jats:italic> study, group Gel received an intramuscular injection of fibrin gel; group Gel+G\u2010CSF<\/jats:styled-content> received fibrin gel containing human G\u2010CSF<\/jats:styled-content>; group Gel+EPO<\/jats:styled-content> received fibrin gel containing human EPO<\/jats:styled-content>; group Gel+G\u2010CSF<\/jats:styled-content>&EPO<\/jats:styled-content> received fibrin gel containing G\u2010CSF<\/jats:styled-content> and EPO<\/jats:styled-content>; group G\u2010CSF<\/jats:styled-content>&EPO<\/jats:styled-content> received G\u2010CSF<\/jats:styled-content> and EPO<\/jats:styled-content>. Through promoting the expression of SDF<\/jats:styled-content>\u20101, local high concentration of EPO<\/jats:styled-content> could traffic CXCR<\/jats:styled-content>4+ cells mobilized by G\u2010CSF<\/jats:styled-content> to enhance neovascularization in ischemic muscle. The treatment with Gel+G\u2010CSF<\/jats:styled-content>&EPO<\/jats:styled-content> was superior to the other treatments on blood flow reperfusion, capillary density, and \u03b1 smooth muscle actin\u2010positive vessel density. And this treatment induced a modest WBC<\/jats:styled-content> count increase in peripheral blood.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>G\u2010CSF<\/jats:styled-content> and EPO<\/jats:styled-content> released from fibrin gel had a combined effect on postischemia neovascularization. This treatment may be a novel therapeutic modality for ischemic peripheral artery disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12037","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T18:50:55Z","timestamp":1357584655000},"page":"416-424","source":"Crossref","is-referenced-by-count":9,"title":["Co\u2010Delivery of G<\/scp>\u2010CSF<\/scp> and EPO<\/scp> Released From Fibrin Gel for Therapeutic Neovascularization in Rat Hindlimb Ischemia Model"],"prefix":"10.1111","volume":"20","author":[{"given":"Feng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery the second affiliated Hospital Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical College Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen 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