{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:29:09Z","timestamp":1792024149281,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:00:00Z","timestamp":1381536000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sepsis is a systemic inflammatory response syndrome. <jats:italic>Emodin<\/jats:italic> is a major ingredient of <jats:italic>Rheum Palmatum<\/jats:italic>, a Chinese herb that is widely used in China for treatment of endotoxemia\u2010related diseases. This study intended to examine the effect of <jats:italic>Emodin<\/jats:italic> on <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced rat mesenteric microcirculatory disturbance and the underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The male Wistar rats received <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> (5 mg\/kg\/hr) for 90 min, with or without administration of <jats:italic>Emodin<\/jats:italic> (10 mg\/kg\/hr) by enema 30 min before (pre\u2010treatment) or after (post\u2010treatment) <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> infusion, and the dynamics of mesenteric microcirculation were determined by inverted intravital microscopy. Expression of adhesion molecules and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB p65, <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u20101 in mesentery tissue was evaluated by flow cytometry and Western\u2010blot, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre or post\u2010treatment with <jats:italic>Emodin<\/jats:italic> significantly ameliorated <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced leukocyte emigration, reactive oxygen species production and albumin leakage, and the expression of <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>4, <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB p65, <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u20101 in mesentery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrate the beneficial role of <jats:italic>Emodin<\/jats:italic> in attenuating the <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced microcirculatory disturbance, and support the use of <jats:italic>Emodin<\/jats:italic> for patients with endotoxemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12061","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T15:52:51Z","timestamp":1364831571000},"page":"617-628","source":"Crossref","is-referenced-by-count":31,"title":["Emodin Improves Lipopolysaccharide\u2010Induced Microcirculatory Disturbance in Rat Mesentery"],"prefix":"10.1111","volume":"20","author":[{"given":"Ang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Li","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"Tasly Microcirculation Research Center Peking University Health Science Center Beijing China"},{"name":"Key Laboratory of 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