{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:40:08Z","timestamp":1780062008612,"version":"3.54.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:00:00Z","timestamp":1381536000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Refractory angina is the occurrence of clinical symptoms despite maximal therapy. We investigated associations between microvascular function, atherosclerotic burden, and clinical symptoms in subjects with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin microvascular response to heating and ischemia was assessed in 167 male volunteers by laser Doppler fluximetry; 82 with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> on maximal therapy and 85 with no known <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> (no<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> scores, carotid <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>, and femoral <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content> were measured and symptoms were scored using the Rose angina questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> had poorer microvascular response to heating (114[95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 106\u2013122]au <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> vs. 143[134\u2013153]au no <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>;<jats:italic> p<\/jats:italic>\u00a0&lt;\u00a00.0001) and ischemia (42[38\u201346]au <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> vs. 53[78\u201358]au. no<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>;<jats:italic> p<\/jats:italic>\u00a0=\u00a00.001). Thirty\u2010eight percent of the no<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group had elevated <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> scores. There were no associations between markers of atherosclerosis and microvascular function. Forty\u2010two percent of the <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> group had refractory angina. This was associated with impaired microvascular function compared to those with elevated <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content> scores but no symptoms (109 [95\u2013124]au vs. 131[122\u2013140]au; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Men with symptomatic <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> have poorer microvascular function compared to individuals without <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. Microvascular function does not correlate with atherosclerosis, but is impaired in individuals with refractory angina. Microvascular dysfunction may play a role in the symptomatology of angina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12066","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T06:18:40Z","timestamp":1368857920000},"page":"670-677","source":"Crossref","is-referenced-by-count":14,"title":["Attenuated Systemic Microvascular Function in Men with Coronary Artery Disease is Associated with Angina but not Explained by Atherosclerosis"],"prefix":"10.1111","volume":"20","author":[{"given":"W. 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspal","family":"Kooner","sequence":"additional","affiliation":[{"name":"International Centre for Circulatory Health NHLI Division Faculty of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nish","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"International Centre for Circulatory Health NHLI Division Faculty of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Shore","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Clinical Science NIHR Exeter Clinical Research Facility University of Exeter Medical School University of Exeter Exeter 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