{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:44:10Z","timestamp":1791207850898,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Several works highlight the role of CsA in the prevention of <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>, but none focus on isolated lungs. Our objective was to evaluate the effects of CsA on IRI on <jats:italic>ex vivo<\/jats:italic> reperfused pig lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two pairs of pig lungs were collected and stored for 30\u00a0minutes at 4\u00b0C. The study was performed in four groups. First, a control group and then three groups receiving different concentrations of CsA (1, 10, and 30\u00a0\u03bcM) at two different times: once at the moment of lung procurement and another during the reperfusion procedure. The <jats:italic>ex vivo<\/jats:italic> lung preparation was set up using an extracorporeal perfusion circuit. Gas exchange parameters, pulmonary hemodynamics, and biological markers of lung injury were collected for the evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CsA improved the PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio, but it also increased PAP, Pcap, and pulmonary vascular resistances with dose\u2010dependent effects. Lungs treated with high doses of CsA displayed higher capillary\u2010alveolar permeability to proteins, lower AFC capacities, and elevated concentrations of pro\u2010inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest a possible deleterious imbalance between the beneficial cell properties of CsA in <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content> and its hemodynamic effects on microvascularization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12082","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T13:47:17Z","timestamp":1376660837000},"page":"84-92","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Cyclosporine A in <i>Ex Vivo<\/i> Reperfused Pig Lungs"],"prefix":"10.1111","volume":"21","author":[{"given":"St\u00e9phane","family":"Gennai","sequence":"first","affiliation":[{"name":"Emergency Department Grenoble University Hospital Grenoble Cedex France"},{"name":"TIMC IMAG Laboratory UMR 5525 La Tronche Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redha","family":"Souilamas","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department European Georges Pompidou Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Maignan","sequence":"additional","affiliation":[{"name":"Emergency Department Grenoble University Hospital Grenoble Cedex France"},{"name":"TIMC IMAG Laboratory UMR 5525 La Tronche Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Brouta","sequence":"additional","affiliation":[{"name":"TIMC IMAG Laboratory UMR 5525 La Tronche Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pison","sequence":"additional","affiliation":[{"name":"Laboratory of Fundamental and Applied Bioenergetics INSERM U1055 Joseph Fourier University Grenoble Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Laboratory of Fundamental and Applied Bioenergetics INSERM U1055 Joseph Fourier University Grenoble Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Briot","sequence":"additional","affiliation":[{"name":"Emergency Department Grenoble University Hospital Grenoble Cedex France"},{"name":"TIMC IMAG Laboratory UMR 5525 La Tronche Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.09.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1152\/jappl.1998.84.3.1011","article-title":"Blood flow vs. venous pressure effects on filtration coefficient in oleic acid\u2010injured lung","volume":"84","author":"Anglade D","year":"1998","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1152\/jappl.1992.73.4.1351","article-title":"Theoretical analysis of occlusion techniques for measuring pulmonary capillary pressure","volume":"73","author":"Baconnier PF","year":"1992","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00027"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680701647410"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8137"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0919"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1986.tb02966.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.095588"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00824.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.1.161"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014597"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-670SO"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00251.2010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.08.078"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1681\/ASN.V48s30","article-title":"Hypertension after renal transplantation","volume":"4","author":"First MR","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00256.2006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1999.tb01211.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01378.2006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1993.1162"},{"key":"e_1_2_10_22_1","unstructured":"International Society for Heart and Lung Transplantation.Annual report.2010."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206b3ca"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/74.5.563"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1976OC"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.120351"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00382-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200003150-00049"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000173594.69089.a0"},{"key":"e_1_2_10_30_1","first-page":"928","article-title":"Hypertension after lung transplantation","volume":"12","author":"Morrison RJ","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03746-3"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000181336.96511.32"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.03.029"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071142"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/81.6.905"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq028"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.01.866"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(96)00288-9"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009133231101"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199412150-00003"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.011"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6135.2003.00277.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1896.sp000596"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00191-7"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001010050298"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1998.5297"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200509-1477OC"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01214-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"e_1_2_10_50_1","first-page":"2679","article-title":"Long\u2010term side effects of cyclosporine\u2010based immunosuppression in patients after liver transplantation","volume":"26","author":"Winkler M","year":"1994","journal-title":"Transplant Proc"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200112150-00008"}],"container-title":["Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmicc.12082","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/micc.12082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T17:43:55Z","timestamp":1694540635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/micc.12082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/micc.12082"],"URL":"https:\/\/doi.org\/10.1111\/micc.12082","archive":["Portico"],"relation":{},"ISSN":["1073-9688","1549-8719"],"issn-type":[{"value":"1073-9688","type":"print"},{"value":"1549-8719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}