{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:57:44Z","timestamp":1787507864169,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL098215"],"award-info":[{"award-number":["HL098215"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR018766"],"award-info":[{"award-number":["RR018766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study investigated the roles of the H1 and H2 histamine receptors,\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      synthase, and s\n                      <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                      cyclase in histamine\u2010induced modulation of rat mesenteric collecting lymphatic pumping.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Isolated rat mesenteric collecting lymphatics were treated with 1\u2010 to 100\u2010\n                      <jats:italic>\u03bc<\/jats:italic>\n                      M histamine. Histamine receptors were blocked with either the H1 antagonist mepyramine or the H2 antagonist cimetidine. The role of\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      \/s\n                      <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                      signaling was tested using the arginine analog\n                      <jats:sc>l<\/jats:sc>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>\n                      , the s\n                      <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                      inhibitor\n                      <jats:styled-content style=\"fixed-case\">ODQ<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                      as a positive control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histamine applied at 100\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      M decreased tone and\n                      <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\n                      of isolated rat mesenteric collecting lymphatics. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine. Pretreatment with\n                      <jats:styled-content style=\"fixed-case\">ODQ<\/jats:styled-content>\n                      , but not\n                      <jats:sc>l<\/jats:sc>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content>\n                      , completely inhibited the histamine\u2010induced decrease in tone.\n                      <jats:styled-content style=\"fixed-case\">ODQ<\/jats:styled-content>\n                      pretreatment also significantly inhibited\n                      <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>\n                      \u2010induced lymphatic relaxation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      H1 and H2 histamine receptors are both involved in histamine\u2010induced relaxation of rat mesenteric collecting lymphatics.\n                      <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                      synthesis does not appear to contribute to the histamine\u2010induced response. However, s\n                      <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                      is critical for the histamine\u2010induced decrease in tone and contributes to the drop in\n                      <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.12138","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T09:31:35Z","timestamp":1396603895000},"page":"593-605","source":"Crossref","is-referenced-by-count":33,"title":["Involvement of H1 and H2 Receptors and Soluble Guanylate Cyclase in Histamine\u2010Induced Relaxation of Rat Mesenteric Collecting Lymphatics"],"prefix":"10.1111","volume":"21","author":[{"given":"Kristine H.","family":"Kurtz","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine Louisiana State University Health Sciences Center\u2010New Orleans New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea N.","family":"Moor","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia M.","family":"Souza\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Louisiana State University Health Sciences Center\u2010New Orleans New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome W.","family":"Breslin","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2545"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0700-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506289102"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1947.27.3.436"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00378.2012"},{"key":"e_1_2_8_7_1","first-page":"409","article-title":"Constriction of perfused lymphatics by acetylcholine, bradykinin and histamine","volume":"6","author":"Dobbins DE","year":"1990","journal-title":"Microcirc Endothelium Lymphatics"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007280"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.1994.1024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(88)90046-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90172-I"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704820"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002907"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.016642"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.258681"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.115212"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0022-3565(25)38732-X","article-title":"Effects of vasoactive substances on the pig isolated hepatic lymph vessels","volume":"269","author":"Hashimoto S","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(83)90138-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085108"},{"key":"e_1_2_8_20_1","first-page":"H720","article-title":"Endothelium\u2010associated vasodilators in rat skeletal muscle microcirculation","volume":"256","author":"Kaley G","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.3.465"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00392.2012"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.3.R790"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/290805"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584242"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0012496610030038"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680600556902"},{"key":"e_1_2_8_28_1","unstructured":"RasbandWS.ImageJ U. S. National Institutes of Health Bethesda Maryland USA.http:\/\/rsb.info.nih.gov\/ij\/ 1997\u20132005."},{"key":"e_1_2_8_29_1","first-page":"H2501","article-title":"Characterization of the effects of histamine in porcine tracheobronchial lymph vessels","volume":"271","author":"Reeder LB","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00002.2003"},{"key":"e_1_2_8_31_1","first-page":"3438","article-title":"Measurement of cytosolic Ca2\u00a0+\u00a0 in isolated contractile lymphatics","volume":"58","author":"Souza\u2010Smith FM","year":"2011","journal-title":"J Vis Exp"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2010.00050.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12032"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0022-3565(25)12591-3","article-title":"Effects of vasoconstrictive and vasodilative agents on lymphatic smooth muscles in isolated canine thoracic ducts","volume":"254","author":"Takahashi N","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01037.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05715.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.6.H2707"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(88)90025-8"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.264.5.H1734"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1152\/ajplegacy.1975.228.5.1326","article-title":"Micromanipulation of pressure in terminal lymphatics in the mesentery","volume":"228","author":"Zweifach BW","year":"1975","journal-title":"Am J Physiol"}],"container-title":["Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmicc.12138","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/micc.12138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T03:44:57Z","timestamp":1746157497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/micc.12138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/micc.12138"],"URL":"https:\/\/doi.org\/10.1111\/micc.12138","archive":["Portico"],"relation":{},"ISSN":["1073-9688","1549-8719"],"issn-type":[{"value":"1073-9688","type":"print"},{"value":"1549-8719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}