{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:29:09Z","timestamp":1790393349181,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["AG-030578"],"award-info":[{"award-number":["AG-030578"]}]},{"name":"NIH","award":["HL-094269"],"award-info":[{"award-number":["HL-094269"]}]},{"name":"Texas A&M University Health Science Center College of Medicine and Department of Medical Physiology","award":["Start up funds"],"award-info":[{"award-number":["Start up funds"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The knowledge of the basic principles of lymphatic function, still remains, to a large degree, rudimentary and will require significant research efforts. Recent studies of the physiology of the MLVs suggested the presence of an EDRF other than NO. In this study, we tested the hypothesis that lymphatic endothelium\u2010derived histamine relaxes MLVs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We measured and analyzed parameters of lymphatic contractility in isolated and pressurized rat MLVs under control conditions and after pharmacological blockade of NO by\n                      <jats:sc>l<\/jats:sc>\n                      \u2010NAME (100\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      M) or\/and histamine production by\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010MHD (10\u00a0\n                      <jats:italic>\u03bc<\/jats:italic>\n                      M). Effectiveness of\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2010MHD was confirmed immunohistochemically. We also used immunohistochemical labeling and Western blot analysis of the histamine\u2010producing enzyme, HDC. In addition, we blocked HDC protein expression in MLVs by transient transfection with vivo\u2010morpholino oligos.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that only combined pharmacological blockade of NO and histamine production completely eliminates flow\u2010dependent relaxation of lymphatic vessels, thus confirming a role for histamine as an EDRF in MLVs. We also confirmed the presence of HDC and histamine inside lymphatic endothelial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports a role for histamine as an EDRF in MLVs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.12143","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T11:08:44Z","timestamp":1398078524000},"page":"640-648","source":"Crossref","is-referenced-by-count":67,"title":["Involvement of Histamine in Endothelium\u2010Dependent Relaxation of Mesenteric Lymphatic Vessels"],"prefix":"10.1111","volume":"21","author":[{"given":"Irina Tsoy","family":"Nizamutdinova","sequence":"first","affiliation":[{"name":"Department of Medical Physiology College of Medicine Texas A&amp;M University Health Science Center Temple Texas 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