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Local tissues can adapt to this challenge by stimulating vascular remodeling through angiogenesis and arteriogenesis thereby restoring blood perfusion and removal of wastes. Multiple molecular mechanisms of vascular remodeling during ischemia have been identified and extensively studied. However, therapeutic benefits from these findings and insights are limited due to the complexity of various signaling networks and a lack of understanding central metabolic regulators governing these responses. The gasotransmitters NO and H<jats:sub>2<\/jats:sub>S have emerged as master regulators that influence multiple molecular targets necessary for ischemic vascular remodeling. In this review, we discuss how NO and H<jats:sub>2<\/jats:sub>S are individually regulated under ischemia, what their roles are in angiogenesis and arteriogenesis, and how their interaction controls ischemic vascular remodeling.<\/jats:p>","DOI":"10.1111\/micc.12248","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T15:31:27Z","timestamp":1442590287000},"page":"134-145","source":"Crossref","is-referenced-by-count":36,"title":["Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling"],"prefix":"10.1111","volume":"23","author":[{"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[{"name":"Departments of Pathology, Molecular and Cellular Physiology, and Cell Biology and Anatomy LSU Health Shreveport Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Kevil","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Molecular and Cellular 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