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We tested whether treprostinil iontophoresis on the finger pad of patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c would improve digital blood flow during hand cooling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c underwent a double\u2010blinded iontophoresis of treprostinil (2.56\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>\u00a0M during two hours) and placebo (NaCl 0.9%) on two finger pads. Then, the hand was inserted for 30\u00a0minutes in a fenestrated cooling box at 8\u00b0C, and skin blood flow was recorded continuously using LSCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the local cooling, CVC was significantly higher at the treprostinil site than at the placebo site and remained higher 30\u00a0minutes after the test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, digital treprostinil iontophoresis shifts skin blood flow upward during local cooling of the hand and during the initial rewarming phase. Digital treprostinil iontophoresis should now be tested in larger scale studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12272","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T08:58:26Z","timestamp":1454317106000},"page":"266-270","source":"Crossref","is-referenced-by-count":10,"title":["Treprostinil Iontophoresis Improves Digital Blood Flow during Local Cooling in Systemic Sclerosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Florence","family":"Gaillard\u2010Bigot","sequence":"first","affiliation":[{"name":"University Grenoble Alpes Grenoble France"},{"name":"Clinical Pharmacology Unit INSERM CIC1406 Grenoble University Hospital Grenoble France"},{"name":"INSERM U1042, HP2 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Roustit","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes Grenoble France"},{"name":"Clinical Pharmacology Unit INSERM CIC1406 Grenoble 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