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Thereafter, the<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>group received the centrally acting sympatho\u2010modulatory drugs clonidine (0.1\u00a0mg\/kg) or rilmenidine (1\u00a0mg\/kg) or vehicle (<jats:italic>n<\/jats:italic>\u00a0=\u00a010\/group) orally by gavage.<jats:styled-content style=\"fixed-case\">FCD<\/jats:styled-content>was evaluated using intravital video microscopy, and the<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>was evaluated using histochemical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pharmacological modulation of the<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>induced concomitant reductions in<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>and plasma catecholamine levels. These effects were accompanied by a reversal of functional and structural capillary rarefaction in the skeletal muscle in both treated groups and an increase in<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>in the left ventricle only in the rilmenidine group. Improvement of the lipid profile and of glucose intolerance was also obtained only with rilmenidine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Modulation of sympathetic overactivity results in the reversal of microvascular rarefaction in the skeletal muscle and left ventricle and improves metabolic parameters in an experimental model of MS in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12280","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T11:56:40Z","timestamp":1460980600000},"page":"320-329","source":"Crossref","is-referenced-by-count":8,"title":["Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High\u2010Fat Diet\u2010Induced Metabolic Syndrome"],"prefix":"10.1111","volume":"23","author":[{"given":"Alessandro R.","family":"Nascimento","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Investigation Oswaldo Cruz Institute FIOCRUZ Rio de 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