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In search of this phenomenon's mechanism, the effect of <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> deformability, a major determinant of blood flow, on transfusion outcome was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> deformability was examined by the transfusion\u2010induced change in recipients\u2019 \u2206<jats:styled-content style=\"fixed-case\">SBF<\/jats:styled-content>, in \u03b2\u2010TM patients, who are routinely treated with lifelong frequent transfusions. <jats:styled-content style=\"fixed-case\">SBF<\/jats:styled-content> was determined using a laser Doppler imager.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u2206<jats:styled-content style=\"fixed-case\">SBF<\/jats:styled-content> was examined vs <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> deformability, the transfusion\u2010induced increase in \u2206Hct and the recipients\u2019 <jats:styled-content style=\"fixed-case\">SBF<\/jats:styled-content> before transfusion (<jats:styled-content style=\"fixed-case\">SBF<jats:sub>B<\/jats:sub><\/jats:styled-content>). \u2206<jats:styled-content style=\"fixed-case\">SBF<\/jats:styled-content> elevated with increasing <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> deformability, with a highly significant dependence, while its elevation with \u2206Hct was much less significant. \u2206<jats:styled-content style=\"fixed-case\">SBF<\/jats:styled-content> was inversely proportional to the <jats:styled-content style=\"fixed-case\">SBF<jats:sub>B<\/jats:sub><\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides, for the first time in humans, direct evidence that the deformability of transfused <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> is a potent effector of transfusion outcome. Currently, <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> are supplied primarily by the first\u2010in\u2013first\u2010out criteria, while their functionality is ignored. The testing of <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> hemodynamic quality would introduce a new paradigm into blood banking, which would contribute substantially to improving transfusion therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12296","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T03:56:40Z","timestamp":1468382200000},"page":"479-486","source":"Crossref","is-referenced-by-count":57,"title":["Deformability of transfused red blood cells is a potent determinant of transfusion\u2010induced change in recipient's blood flow"],"prefix":"10.1111","volume":"23","author":[{"given":"Gregory","family":"Barshtein","sequence":"first","affiliation":[{"name":"Department of Biochemistry Hebrew University Faculty of Medicine  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel R.","family":"Pries","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin 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