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This can be explained by <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content> due to adverse remodeling of coronary arterioles which have also been reported in the <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare the effects of ramipril, perindopril, candesartan, atenolol, amlodipine, indapamide, and <jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content>1766 on <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight groups of 24\u2010wk\u2010old <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> were treated for 8\u00a0wk. <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was measured invasively at the end of the treatment. After sacrifice, hearts were mounted on a Langendorff apparatus for the measurement of hyperemic <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Hearts were then processed for histomorphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All compounds, except <jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content>1766, induced a significant reduction in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Perindopril and candesartan increased hyperemic <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>, whereas the other compounds had no significant effect. Perindopril, ramipril, atenolol, indapamide, and <jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content>1766 induced significant reverse arteriolar remodeling, whereas candesartan and amlodipine did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effect of antihypertensive treatment on <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content> is not exclusively dependent on <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> reduction. Compounds with comparable antihypertensive efficacy may exert different effects on <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> and induce different degrees of reverse arteriolar remodeling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12298","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T14:42:44Z","timestamp":1469112164000},"source":"Crossref","is-referenced-by-count":9,"title":["Effect of different drug classes on reverse remodeling of intramural coronary arterioles in the spontaneously hypertensive rat"],"prefix":"10.1111","volume":"24","author":[{"given":"Massimiliano","family":"Mancini","sequence":"first","affiliation":[{"name":"Istituto \u201cMarco Pasquali\u201d ICOT GIOMI  Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Scavone","sequence":"additional","affiliation":[{"name":"Vita Salute University and Scientific Institute San Raffaele  Milan 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