{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:28:09Z","timestamp":1767677289024,"version":"3.37.3"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010308","name":"Heinz-Horst Deichmann Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010308","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Stent implantation into atherosclerotic coronary vessels induces the release of particulate debris and soluble vasoactive substances, which impair downstream microvascular function. Microvascular perfusion, however, is also determined by hemorheological parameters. We therefore analyzed now changes in erythrocyte (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) aggregation in coronary arterial blood during stent implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Symptomatic male patients with stable angina pectoris and stenosis in their native right coronary artery (<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>) or saphenous vein graft on right coronary artery (<jats:styled-content style=\"fixed-case\">SVG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>) were enrolled. Coronary arterial blood was taken before and coronary aspirate during stent implantation with a distal occlusion\/aspiration device. <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> aggregation was determined using the erythrocyte adhesiveness\/aggregation test. The ratio of clot\u2010free area to whole area of a spread blood drop was quantified (<jats:styled-content style=\"fixed-case\">rCFA<\/jats:styled-content>). To evaluate the impact of soluble factors within aspirate plasma on <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> aggregation, separated <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s of healthy volunteers were exposed to patients' coronary arterial blood and aspirate samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">rCFA<\/jats:styled-content> was comparably increased in coronary aspirate of <jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SVG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>s after stent implantation (<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>: 25.7\u00b12.1% vs 32.2\u00b12.1%; <jats:styled-content style=\"fixed-case\">SVG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>: 28.9\u00b11.9% vs 33.3\u00b12.0%, <jats:italic>P<\/jats:italic>&lt;.01). The <jats:styled-content style=\"fixed-case\">rCFA<\/jats:styled-content> of healthy volunteers was increased after adding coronary aspirate plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stent implantation into atherosclerotic coronary arteries induces an increase in <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> aggregation, potentially contributing to impaired microvascular perfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12326","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T01:49:30Z","timestamp":1476409770000},"page":"637-645","source":"Crossref","is-referenced-by-count":6,"title":["Influence of stent implantation on erythrocyte aggregation in human native coronary arteries and saphenous vein grafts"],"prefix":"10.1111","volume":"23","author":[{"given":"Theodor","family":"Baars","sequence":"first","affiliation":[{"name":"Institute for Pathophysiology West German Heart and 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