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Structural, functional, and extravascular abnormalities of the microcirculation lead to <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content> can present with symptoms suggestive of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, often in the absence of significant obstructive epicardial <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>. Conventional invasive angiography does not allow direct visualization of the microcirculation. Invasive indices, such as <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CFR<\/jats:styled-content>, and non\u2010invasive imaging modalities, such as <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>, can be used to quantify absolute MBF and enable a direct and accurate assessment of coronary microvascular function. <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content> appears to be more prevalent in women, typically presenting with symptoms of ischemia with unobstructed coronary arteries, and has a relatively unfavorable prognosis. <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content> is classified clinically depending on the presence or absence of epicardial <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, myocardial disease, or iatrogenic causes. Although invasive intracoronary techniques can be used to detect <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content>, these cannot provide insight into the mechanisms involved in its pathogenesis. Imaging modalities such as <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> and cardiac <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> are becoming indispensable tools in the evaluation of suspected <jats:styled-content style=\"fixed-case\">CMD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/micc.12340","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T18:25:26Z","timestamp":1481826326000},"source":"Crossref","is-referenced-by-count":37,"title":["Current perspectives in coronary microvascular dysfunction"],"prefix":"10.1111","volume":"24","author":[{"given":"Joy S.","family":"Shome","sequence":"first","affiliation":[{"name":"Division of Imaging Sciences and Biomedical Engineering The Rayne Institute King's College London St. Thomas\u2019 Hospital  London 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