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While most previous studies focused on endpoints of such adaptive changes in larger collaterals, the present investigation aimed to continuously determine the relation between <jats:styled-content style=\"fixed-case\">WSS<\/jats:styled-content> and diameter in microvascular collaterals during adaptive reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In Hamburger\u2010Hamilton stage 40 <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>s, junction points between arteriolar segments were identified and the third upstream segment on one side was occluded. Intravital microscopy recordings were taken for 24\u00a0hours post\u2010occlusion. Segment diameter and blood velocity were measured: <jats:styled-content style=\"fixed-case\">WSS<\/jats:styled-content> and capillary density were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After occlusion, vascular diameters exhibited an immediate decrease, then increased with a time constant of 2.5\u00a0\u00b1\u00a00.8\u00a0hours and reached a plateau of up to 60% above baseline after about 7\u00a0hours. Vascular tone showed no significant change. <jats:styled-content style=\"fixed-case\">WSS<\/jats:styled-content> exhibited an immediate increase post\u2010occlusion and linearly returned to baseline after about 12\u00a0hours. Local <jats:styled-content style=\"fixed-case\">WSS<\/jats:styled-content> change and diameter change rate showed similar patterns during the initial but not the later phase of post\u2010occlusive adaptation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> collaterals undergo fast structural remodeling within 24\u00a0hours post\u2010occlusion. This remodeling might be driven by local <jats:styled-content style=\"fixed-case\">WSS<\/jats:styled-content> and by other regulators within the vascular network.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12351","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T16:03:17Z","timestamp":1484150597000},"source":"Crossref","is-referenced-by-count":10,"title":["Dynamic remodeling of arteriolar collaterals after acute occlusion in chick chorioallantoic membrane"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-7970","authenticated-orcid":false,"given":"Weiwei","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Physiology Charit\u00e9 Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Reglin","sequence":"additional","affiliation":[{"name":"Department of Physiology Charit\u00e9 Berlin  Berlin 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