{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:52Z","timestamp":1790790352803,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Limburg Clinical Research Program (LCRP) UHasselt -ZOL -Jessa"},{"DOI":"10.13039\/501100009542","name":"Limburg Sterk Merk (LSM)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009542","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009550","name":"Hasselt University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ziekenhuis Oost-Limburg and Jessa Hospital"},{"name":"Research Foundation -Flanders","award":["1127917N"],"award-info":[{"award-number":["1127917N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Endothelial glycocalyx degradation has been associated with multiple pathophysiological processes in cardiovascular disease.<\/jats:p><\/jats:sec>Aims<\/jats:title>To explore the role of glycocalyx shedding markers in pathophysiology of HFrEF.<\/jats:p><\/jats:sec>Methods<\/jats:title>In 123 HFrEF patients, the concentration, prognostic value, and association of glycocalyx shedding markers with other disease processes were investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>Median HA<\/jats:styled-content> levels and syndecan\u20101 levels in HF<\/jats:styled-content>rEF<\/jats:styled-content> patients were, respectively, 29.4 (10.7;61.6) ng\/mL and 48.5 (33.6;80.8) ng\/mL. Overall, HA<\/jats:styled-content>\u2010levels were significantly higher in HF<\/jats:styled-content>rEF<\/jats:styled-content> patients compared to healthy subjects, but only 31% of HF<\/jats:styled-content>rEF<\/jats:styled-content> patients had HA<\/jats:styled-content>\u2010levels above the cutoff of normal. There was no significant difference among HF<\/jats:styled-content>rEF<\/jats:styled-content> patients and healthy subjects regarding syndecan\u20101 levels. HF<\/jats:styled-content>rEF<\/jats:styled-content> patients with elevated HA<\/jats:styled-content>\u2010levels had a significantly worse outcome (log rank\u00a0=\u00a00.01) which remained significant after correction for established risk factors (HR<\/jats:styled-content> 2.53 (1.13\u20105.69); P<\/jats:italic>\u00a0=\u00a0.024). There was no significant relation between levels of shedding markers and neurohumoral activation (PRA, serum aldosterone, NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content>), myocardial injury (HS<\/jats:styled-content>\u2010trop), inflammation (CRP<\/jats:styled-content>), or other baseline characteristics.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The glycocalyx shedding marker HA<\/jats:styled-content> is significantly elevated in a subgroup of HF<\/jats:styled-content>rEF<\/jats:styled-content> patients and an independent predictor for worse clinical outcome. Glycocalyx shedding might be an additional factor in the pathophysiology of HF<\/jats:styled-content> which warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12432","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T05:02:53Z","timestamp":1512536573000},"source":"Crossref","is-referenced-by-count":12,"title":["Endovascular shedding markers in patients with heart failure with reduced ejection fraction"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-7734","authenticated-orcid":false,"given":"Petra","family":"Nijst","sequence":"first","affiliation":[{"name":"Department of Cardiology Ziekenhuis Oost\u2010Limburg Genk Belgium"},{"name":"Doctoral School for Medicine and Life Sciences Hasselt University Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirka","family":"Cops","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute 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