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Resistant hypertension is an increasingly common clinical problem in older age, obesity, diabetes, sleep apnea, and chronic kidney disease. Although the direct vasodilator minoxidil was introduced in the early 1970s, only recently has this drug been shown to be particularly effective in a subgroup of patients with treatment\u2010resistant or uncontrolled hypertension. This pharmacological approach is interesting from a mechanistic perspective as minoxidil is the only clinically used K<jats:sup>+<\/jats:sup>channel opener today, which targets a subclass of K<jats:sup>+<\/jats:sup>channels, namely<jats:styled-content style=\"fixed-case\">K<jats:sub>ATP<\/jats:sub><\/jats:styled-content>channels in<jats:styled-content style=\"fixed-case\">VSMC<\/jats:styled-content>s. Beside<jats:styled-content style=\"fixed-case\">K<jats:sub>ATP<\/jats:sub><\/jats:styled-content>channels, two other classes of<jats:styled-content style=\"fixed-case\">VSMC<\/jats:styled-content>K<jats:sup>+<\/jats:sup>channels could represent novel effective targets for treatment of resistant hypertension, namely K<jats:sub>v<\/jats:sub>7 (<jats:styled-content style=\"fixed-case\">KCNQ<\/jats:styled-content>) and inward rectifier potassium (K<jats:sub>ir<\/jats:sub>2.1) channels. Interestingly, these channels are unique among<jats:styled-content style=\"fixed-case\">VSMC<\/jats:styled-content>potassium channels. First, both have been implicated in the control of microvascular tone by perivascular adipose tissue. Second, they exhibit biophysical properties strongly controlled and regulated by membrane voltage, but not intracellular calcium. This review focuses on K<jats:sub>v<\/jats:sub>7 (K<jats:sub>v<\/jats:sub>7.1\u20105) and K<jats:sub>ir<\/jats:sub>(K<jats:sub>ir<\/jats:sub>2.1) channels in<jats:styled-content style=\"fixed-case\">VSMC<\/jats:styled-content>s as potential novel drug targets for treatment of resistant hypertension, particularly in comorbid conditions such as obesity and metabolic syndrome.<\/jats:p>","DOI":"10.1111\/micc.12434","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T14:52:41Z","timestamp":1512571961000},"source":"Crossref","is-referenced-by-count":21,"title":["Perivascular adipose tissue and the dynamic regulation of K<sub>v<\/sub>7 and K<sub>ir<\/sub>channels: Implications for resistant hypertension"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-1934","authenticated-orcid":false,"given":"Maik","family":"Gollasch","sequence":"first","affiliation":[{"name":"Medical Clinic for Nephrology and Internal Intensive 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