{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:36:51Z","timestamp":1753879011278,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>In SS<\/jats:styled-content>c, vascular injury leads to endothelial dysfunction with reduced capillary blood flow and tissue hypoxia. In SS<\/jats:styled-content>c, the angiogenesis is impaired and implicated in the microvascular damage. In severe vascular damage, VEGF<\/jats:styled-content> is reduced and endostatin is increased. The aim of this study was to evaluate the correlation between endostatin serum levels and microvascular and digital arteries damage.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventeen patients with SS<\/jats:styled-content>c were enrolled in this study. Serum endostatin levels were determined. All patients underwent a NVC<\/jats:styled-content>, CDUS<\/jats:styled-content>, and LDPI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The serum level of endostatin significantly (P<\/jats:italic>\u00a0<\u00a0.05) increased with NVC<\/jats:styled-content> progression damage. The mean perfusion significantly (P<\/jats:italic>\u00a0<\u00a0.05) decreased with NVC<\/jats:styled-content> progression damage. Multiple regression analysis showed a significant correlation between endostatin serum level and RI (r<\/jats:italic>\u00a0=\u00a0.34, P<\/jats:italic>\u00a0<\u00a0.05), PI (r<\/jats:italic>\u00a0=\u00a0.60, P<\/jats:italic>\u00a0<\u00a0.01), S\/D ratio (r<\/jats:italic>\u00a0=\u00a0.76, P<\/jats:italic>\u00a0<\u00a0.0001), and mean perfusion (r<\/jats:italic>\u00a0=\u00a0\u2212.68, P<\/jats:italic>\u00a0<\u00a0.001). Endostatin serum levels significantly (P<\/jats:italic>\u00a0<\u00a0.05) increased with progression of CDUS<\/jats:styled-content> damage.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Increased serum endostatin levels are associated with digital vascular damage. In patients with SS<\/jats:styled-content>c, endostatin is a marker of skin perfusion and digital arteries damage of hands.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12449","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:18:03Z","timestamp":1521116283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In systemic sclerosis, microvascular and hands digital arteries damage correlates with serum levels of endostatin"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-765X","authenticated-orcid":false,"given":"Antonietta","family":"Gigante","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Scleroderma Unit Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Navarini","sequence":"additional","affiliation":[{"name":"Department of Immuno\u2010Rheumatology Unit Campus Bio\u2010Medico University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Margiotta","sequence":"additional","affiliation":[{"name":"Department of Immuno\u2010Rheumatology Unit Campus Bio\u2010Medico University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biagio","family":"Barbano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Scleroderma Unit Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Afeltra","sequence":"additional","affiliation":[{"name":"Department of Immuno\u2010Rheumatology Unit Campus Bio\u2010Medico University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Rosato","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Scleroderma Unit Sapienza University 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