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Physiological roles of ion channels and receptors in skeletal muscle and mesenteric arteries have been identified; however, their gene expression profiles are undefined. We tested the hypothesis that expression profiles for ion channels and receptors governing vascular reactivity vary with cell type, vascular bed, and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mesenteric and superior epigastric arteries were dissected from Old (24\u201026\u00a0months) and Young (3\u20106\u00a0months) C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice.<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s and<jats:styled-content style=\"fixed-case\">SMC<\/jats:styled-content>s were collected for analysis with custom<jats:styled-content style=\"fixed-case\">qRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>arrays to determine expression profiles of 80 ion channel and receptor genes. Bioinformatics analyses were applied to gain insight into functional interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 68 differences in gene expression with respect to cell type, vessel type, and age. Heat maps illustrate differential expression, and distance matrices predict patterns of coexpression. Gene networks based upon protein\u2010protein interaction datasets and<jats:styled-content style=\"fixed-case\">KEGG<\/jats:styled-content>pathways illustrate biological processes affected by specific differences in gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in gene expression profiles are most pronounced between microvascular<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>s and<jats:styled-content style=\"fixed-case\">SMC<\/jats:styled-content>s with subtle variations between vascular beds and age groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12452","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T06:57:35Z","timestamp":1522047455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gene expression profiles of ion channels and receptors in mouse resistance arteries: Effects of cell type, vascular bed, and age"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-3485","authenticated-orcid":false,"given":"Erika M.","family":"Boerman","sequence":"first","affiliation":[{"name":"Medical Pharmacology and Physiology School of Medicine University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Sen","sequence":"additional","affiliation":[{"name":"MU Informatics Institute University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Medical Pharmacology and Physiology School of Medicine University of Missouri Columbia MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trupti","family":"Joshi","sequence":"additional","affiliation":[{"name":"MU Informatics Institute University of Missouri Columbia MO USA"},{"name":"Health Management and Informatics and Office of Research School of Medicine University of Missouri Columbia MO USA"},{"name":"Christopher S. 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