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Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by high fat (HF<\/jats:styled-content>) feeding from weaning. Aldosterone, or activation of the mineralocorticoid receptor (MR<\/jats:styled-content>) causes cerebrovascular injury in lean hypertensive rats. We hypothesized that rats fed a HF<\/jats:styled-content> diet would show inward middle cerebral artery (MCA<\/jats:styled-content>) remodeling that could be prevented by MR<\/jats:styled-content> antagonism. We further proposed that the cerebral artery remodeling would be associated with white mater injury.<\/jats:p><\/jats:sec>Methods<\/jats:title>Three\u2010week\u2010old male Sprague\u2010Dawley rats were fed a HF<\/jats:styled-content> diet\u00a0\u00b1\u00a0the MR<\/jats:styled-content> antagonist canrenoic acid (Canr) for 17\u00a0weeks. Control rats received normal chow (control NC<\/jats:styled-content>). MCA<\/jats:styled-content> structure was assessed by pressure myography.<\/jats:p><\/jats:sec>Results<\/jats:title>The MCA<\/jats:styled-content>s from HF<\/jats:styled-content> fed rats had smaller lumens and thicker walls when compared to arteries from control NC<\/jats:styled-content> rats; Canr prevented the MCA<\/jats:styled-content> remodeling associated with HF<\/jats:styled-content> feeding. HF<\/jats:styled-content> feeding increased the mRNA<\/jats:styled-content> expression of markers of cell proliferation and vascular inflammation in cerebral arteries and Canr treatment prevented this. White mater injury was increased in the rats fed the HF<\/jats:styled-content> diet and this was reduced by Canr treatment. The expression of doublecortin, a marker of new and immature neurons was reduced in HF<\/jats:styled-content> fed rats, and MR<\/jats:styled-content> antagonism normalized this.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These data suggest that HF<\/jats:styled-content> feeding leads to MR<\/jats:styled-content> dependent remodeling of the MCA<\/jats:styled-content> and this is associated with markers of dementia development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12460","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T23:24:39Z","timestamp":1526340279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mineralocorticoid receptor antagonism prevents obesity\u2010induced cerebral artery remodeling and reduces white matter injury in rats"],"prefix":"10.1111","volume":"25","author":[{"given":"Paulo W.","family":"Pires","sequence":"first","affiliation":[{"name":"Department 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