{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:02:52Z","timestamp":1776819772377,"version":"3.51.2"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005703","name":"Akdeniz \u00dcniversitesi","doi-asserted-by":"publisher","award":["09.03.0122.011"],"award-info":[{"award-number":["09.03.0122.011"]}],"id":[{"id":"10.13039\/501100005703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this descriptive study was to examine the contribution of CO in the maintenance of vascular tonus in different organs and different vessel segments; the underlying mechanism of CO\u2010induced vasodilation was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty Wistar albino rats, aged 6\u20108\u00a0months, were used in this study. Response to CO by isolated arteries from the thoracic and abdominal aorta and mesenteric, renal, gastrocnemius, and gracilis muscles as well as heart, lung, and brain vascular beds was endogenously and exogenously studied using organ baths or myograph. In addition, HO\u20102 protein expression was assessed using Western blot analysis in isolated vessel segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although CO was shown to contribute to the regulation of vascular tonus in all feed arteries except those of the gracilis vascular bed, no effect was observed in the resistance arteries, with the sole exception of the pial artery. No relationship between HO\u20102 protein level and CO contribution to endogenous vascular tonus was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While the vasodilator effect of CO in vessels smaller than 600\u00a0\u03bcm in diameter was found to be mediated via potassium channels, in vessels larger than 600\u00a0\u03bcm in diameter, the effect was through both the potassium channels and the cGMP pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12495","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T01:32:36Z","timestamp":1532482356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The contribution of carbon monoxide to vascular tonus"],"prefix":"10.1111","volume":"25","author":[{"given":"G\u00fcnnur","family":"Ko\u00e7er","sequence":"first","affiliation":[{"name":"Department of Physiology Medical Faculty Near East University Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seher","family":"Nasircilar \u00dclker","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical Faculty Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-7065","authenticated-orcid":false,"given":"\u00dcmit Kemal","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical Faculty Akdeniz University Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1994.sp003816"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2741\/s183"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2008.00610.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00427.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1139\/y97-187"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480548809018109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117538"},{"issue":"6","key":"e_1_2_10_9_1","first-page":"F882","article-title":"Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS","volume":"277","author":"Thorup C","year":"1999","journal-title":"Am J Physiol"},{"issue":"5","key":"e_1_2_10_10_1","first-page":"H1641","article-title":"Carbon monoxide and cerebral microvascular tone in newborn pigs","volume":"276","author":"Leffler CW","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.9.2306"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1475"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02071-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.12.1224"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000028488.71068.16"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.5.568"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701222"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050398"},{"issue":"2","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada S","year":"1991","journal-title":"Pharmacol Rev"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000255173.50317.fc"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.1.337"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199611000-00014"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91180.2008"},{"key":"e_1_2_10_26_1","unstructured":"RasbandWS.Image J.Bethesda MD:U. 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