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In adult vasculature, H\n                      <jats:sub>2<\/jats:sub>\n                      S is predominantly produced by\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      . We hypothesized that vascular\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      activity contributes to microvascular tone regulation during circulatory transition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Preterm (\n                      <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\n                      62) and full\u2010term (\n                      <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\n                      69) guinea pig fetuses and neonates were studied. Microvascular blood flow was assessed by laser Doppler flowmetry. Thiosulfate, primary urinary metabolite of H\n                      <jats:sub>2<\/jats:sub>\n                      S, was determined by high\u2010performance liquid chromatography. Real\u2010time H\n                      <jats:sub>2<\/jats:sub>\n                      S production was assessed using a microrespiration system in fetal and postnatal (10, 24\u00a0hours) skin and heart samples.\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      contribution was investigated by inhibition via propargylglycine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In preterm animals, postnatal H\n                      <jats:sub>2<\/jats:sub>\n                      S production capacity in peripheral vasculature increased significantly and was significantly reduced by the inhibition of\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      . Urinary thiosulfate correlated with both microvascular blood flow and capacity of the vasculature to produce H\n                      <jats:sub>2<\/jats:sub>\n                      S. H\n                      <jats:sub>2<\/jats:sub>\n                      S produced via\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      did not correlate directly with microvascular blood flow.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In preterm neonates, H\n                      <jats:sub>2<\/jats:sub>\n                      S production increases during fetal\u2010to\u2010neonatal transition and\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      contribution to total H\n                      <jats:sub>2<\/jats:sub>\n                      S increases postnatally.\n                      <jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>\n                      \u2010dependent mechanisms may therefore underpin the increase in H\n                      <jats:sub>2<\/jats:sub>\n                      S production over the first 72\u00a0hours of life in preterm human neonates, associated with both central and peripheral cardiovascular instability.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/micc.12507","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T20:51:03Z","timestamp":1538427063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microvascular circulatory dysregulation driven in part by cystathionine gamma\u2010lyase: A new paradigm for cardiovascular compromise in the preterm newborn"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-6897","authenticated-orcid":false,"given":"Rebecca M.","family":"Dyson","sequence":"first","affiliation":[{"name":"Illawarra Health and 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