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Two hundred patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> stage \u22673 were enrolled in the <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> group, and 50 age\u2010matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus (<jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>) and deep vascular plexus (<jats:styled-content style=\"fixed-case\">DVP<\/jats:styled-content>) between the <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean ages were 62.7\u00a0\u00b1\u00a010.1 in the <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> group and 61.9\u00a0\u00b1\u00a09.7 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.622) in the control group. The <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> group had reduced parafoveal vessel densities in <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content> (46.7\u00a0\u00b1\u00a04.3 vs 49.7\u00a0\u00b1\u00a02.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">DVP<\/jats:styled-content> (50.1\u00a0\u00b1\u00a04.1 vs 52. 6\u00a0\u00b1\u00a02.9, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti\u2010hypertensive drugs were factors associated with vessel density in <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content>, whereas age, diabetes, and smoking were factors associated with vessel density in <jats:styled-content style=\"fixed-case\">DVP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> had reduced vessel densities in parafoveal <jats:styled-content style=\"fixed-case\">SVP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DVP<\/jats:styled-content>, as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12555","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T07:28:55Z","timestamp":1557300535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Early retinal microvascular abnormalities in patients with chronic kidney disease"],"prefix":"10.1111","volume":"26","author":[{"given":"Ling","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Keelung Chang Gung Memorial Hospital Keelung Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Department of Nephrology Keelung Chang Gung 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