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The restored dilation to ACh in MCA of Protandim\u2010treated rats was prevented by inhibiting nitric oxide synthase (NOS) with L\u2010NAME [100 \u03bcM] and was absent in MCA from Nrf2<jats:sup>(\u2212\/\u2212)<\/jats:sup> knockout rats fed HS diet. Basilar arteries from HS\u2010fed rats treated with Protandim exhibited significantly lower staining for mitochondrial oxidizing species than untreated animals fed HS diet alone; and Protandim treatment increased MnSOD (SOD2) protein expression in mesenteric arteries of HS\u2010fed rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that dietary activation of NRF2 protects against salt\u2010induced vascular dysfunction, vascular oxidative stress, and microvascular rarefaction by upregulating antioxidant defenses and reducing mitochondrial ROS levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12575","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T13:44:11Z","timestamp":1558964651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>NRF<\/scp>2 activation with Protandim attenuates salt\u2010induced vascular dysfunction and microvascular rarefaction"],"prefix":"10.1111","volume":"26","author":[{"given":"Jessica R. 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