{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:04:25Z","timestamp":1769065465629,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z171100001017056"],"award-info":[{"award-number":["Z171100001017056"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the changes in sublingual and conjunctival microcirculation occurring with cerebral cortex microcirculation changes during mild hypothermia in a rat model of cardiac arrest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four rats were randomized into mild hypothermia (M) or normothermia (C) groups. Ventricular fibrillation was electrically induced and left untreated for 8\u00a0minutes, followed by 8\u00a0minutes of cardiopulmonary resuscitation. The core temperature in group M reduced to 33\u00a0\u00b1\u00a00.5\u00b0C at 13\u00a0minutes after restoration of spontaneous circulation and was maintained for 8\u00a0hours. In group C, the core temperature was maintained at 37\u00a0\u00b1\u00a00.2\u00b0C. The hemodynamics and microcirculation in the sublingual region, bulbar conjunctiva, and cerebral cortex were measured at baseline and 1, 2, 3, 4, 6, and 8\u00a0hours after restoration of spontaneous circulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The M group showed significantly worse sublingual microcirculation at 6\u00a0hours post\u2010resuscitation. However, microcirculation in the conjunctiva and cerebral cortex at 3\u00a0hours post\u2010resuscitation were better in the M group. In the M group, microcirculation in the cerebral cortex was significantly correlated with that in the conjunctiva but not the sublingual microcirculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Changes in conjunctival microcirculation are closely related to cerebral cortex microcirculation during mild hypothermia, indicating that cerebral cortex microcirculation could be monitored by measuring conjunctival microcirculation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12604","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T07:01:56Z","timestamp":1577343716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Conjunctival microcirculation is associated with cerebral cortex microcirculation in post\u2010resuscitation mild hypothermia: A rat model"],"prefix":"10.1111","volume":"27","author":[{"given":"Shen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Fujian Provincial Hospital Fujian Institute of Emergency Medicine Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Wu","sequence":"additional","affiliation":[{"name":"Weil Institute of Emergency and Critical Care Research School of Medicine Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Tang","sequence":"additional","affiliation":[{"name":"Weil Institute of Emergency and Critical Care Research School of Medicine Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-4099","authenticated-orcid":false,"given":"Ziren","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Beijing Chao\u2010Yang Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing Chao\u2010Yang Hospital Capital Medical University 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