{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:41:30Z","timestamp":1773898890758,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the possible alterations of retinal microcirculation associated with right\u2010sided intracardiac pressures in patients with IPAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with IPAH and 20 age\u2010 and sex\u2010matched healthy controls were included in the study. Hemodynamic data were obtained from the most recent right heart catheterization. Echocardiographic examination was performed within 24\u00a0h of ophthalmological examination. For the right eyes of all participants, high\u2010resolution scans of chorioretinal microvascular networks at different depths of the retina were captured via OCT angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The perfusion of the super\ufb01cial and deep capillary plexus (SCP and DCP), and choriocapillaris (CCP) flow area were significantly lower than those in healthy control subjects (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05 for all). In IPAH group, PVR and mPAP were correlated significantly with the perfusion measurements at SCP and DCP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.461, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.626 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0.625, r =0.730, respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). sPAP and TRV were positively correlated with the perfusion measurements at SCP and DCP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.600, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.662 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0.670, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.655 <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The positive correlation of retinal perfusion at SCP and DCP with right\u2010sided echocardiographic and hemodynamic measurements unveiled that retinal microcirculation is affected by the pressure alterations in the pulmonary circulation of IPAH patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/micc.12704","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T18:53:49Z","timestamp":1620672829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The relationship between retinal microcirculation and right heart catheterization and echocardiography findings in patients with idiopathic pulmonary arterial hypertension"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-894X","authenticated-orcid":false,"given":"Vedat","family":"Hekimsoy","sequence":"first","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilal","family":"K\u0131l\u0131n\u00e7 Hekimsoy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ulucanlar Eye Training and Research Hospital  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